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1.
Pharmacological Characterization of the Novel and Selective α7 Nicotinic Acetylcholine Receptor-Positive Allosteric Modulator BNC375.
J Pharmacol Exp Ther
; 373(2): 311-324, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32094294
2.
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
ACS Med Chem Lett
; 14(2): 146-155, 2023 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-36793422
3.
Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
ACS Med Chem Lett
; 14(8): 1088-1094, 2023 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37583812
4.
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task.
J Neurogenet
; 25(4): 120-6, 2011 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22070409
5.
Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey.
Neuropharmacology
; 197: 108754, 2021 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34389398
6.
Nav1.7 target modulation and efficacy can be measured in nonhuman primate assays.
Sci Transl Med
; 13(594)2021 05 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34011626
7.
Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects.
J Pain Res
; 11: 735-741, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29692626
8.
Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity.
Psychopharmacology (Berl)
; 233(13): 2441-50, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27117142
9.
The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model.
Behav Brain Res
; 287: 96-9, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25800972
10.
Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey.
Psychopharmacology (Berl)
; 232(11): 1859-66, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25491927
11.
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Neuropharmacology
; 64: 215-23, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22750078
12.
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats.
Neuropharmacology
; 62(3): 1413-21, 2012 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21110986
13.
MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?
Pharmacol Biochem Behav
; 95(2): 223-9, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20122952
14.
T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine.
Biol Psychiatry
; 68(8): 712-8, 2010 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20579972
15.
Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants.
Psychopharmacology (Berl)
; 206(4): 641-51, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19707745
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