Detalles de la búsqueda
1.
Significance of Organic Anion Transporter 2 and Organic Cation Transporter 2 in Creatinine Clearance: Mechanistic Evaluation Using Freshly Prepared Human Primary Renal Proximal Tubule Cells.
J Pharmacol Exp Ther
; 388(1): 201-208, 2024 01 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37977812
2.
Low molecular weight acids and OATP1B mediated hepatic clearance: In vitro and in vivo evaluation using novel hypoxia-inducible factor prolyl hydroxylase inhibitors (Dustats).
Drug Metab Dispos
; 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38388380
3.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35779864
4.
Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 377(1): 169-180, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33509903
5.
Effect of Human Plasma on Hepatic Uptake of Organic Anion-Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes.
Drug Metab Dispos
; 49(1): 72-83, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33139461
6.
Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides: Where Is the Evidence for Its Relevance in Drug-Drug Interactions?
Drug Metab Dispos
; 48(3): 205-216, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31879282
7.
In Vivo-to-In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach.
Drug Metab Dispos
; 49(6): 470-478, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33824168
8.
Cytochrome-P450-Mediated Drug-Drug Interactions of Substrate Drugs: Assessing Clinical Risk Based on Molecular Properties and an Extended Clearance Classification System.
Mol Pharm
; 17(8): 3024-3032, 2020 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32589434
9.
Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.
J Pharmacol Exp Ther
; 370(1): 72-83, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30975793
10.
Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1.
Drug Metab Dispos
; 47(5): 493-503, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30862625
11.
Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
J Pharmacol Exp Ther
; 367(2): 322-334, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30135178
12.
Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug.
J Pharmacol Exp Ther
; 364(3): 390-398, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29326367
13.
In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 365(3): 688-699, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29643253
14.
Navigating Transporter Sciences in Pharmacokinetics Characterization Using the Extended Clearance Classification System.
Drug Metab Dispos
; 46(5): 729-739, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29496721
15.
Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein.
Drug Metab Dispos
; 46(8): 1200-1211, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29739809
16.
Comparison of Proteomic Quantification Approaches for Hepatic Drug Transporters: Multiplexed Global Quantitation Correlates with Targeted Proteomic Quantitation.
Drug Metab Dispos
; 46(5): 692-696, 2018 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439128
17.
Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey.
Drug Metab Dispos
; 46(8): 1179-1189, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29880631
18.
Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.
Drug Metab Dispos
; 46(7): 989-1000, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29720472
19.
Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.
Mol Pharm
; 15(8): 3227-3235, 2018 08 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29906129
20.
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.
Mol Pharm
; 15(3): 1284-1295, 2018 03 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29433307