Detalles de la búsqueda
1.
Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates.
Arch Toxicol
; 94(9): 3027-3032, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32472168
2.
A Comparative Linear Interaction Energy and MM/PBSA Study on SIRT1-Ligand Binding Free Energy Calculation.
J Chem Inf Model
; 59(9): 4018-4033, 2019 09 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31461271
3.
Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations.
Chem Res Toxicol
; 31(2): 116-126, 2018 02 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-29281794
4.
Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion.
Amino Acids
; 50(10): 1377-1390, 2018 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-29978260
5.
Binding free energy predictions of farnesoid X receptor (FXR) agonists using a linear interaction energy (LIE) approach with reliability estimation: application to the D3R Grand Challenge 2.
J Comput Aided Mol Des
; 32(1): 239-249, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28889350
6.
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners.
Appl Microbiol Biotechnol
; 102(21): 9231-9242, 2018 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-30136203
7.
Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine.
Br J Clin Pharmacol
; 83(3): 572-583, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27718269
8.
Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors.
J Chem Inf Model
; 57(9): 2294-2308, 2017 09 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28776988
9.
Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations.
Proteins
; 84(3): 383-96, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26757175
10.
Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.
Chem Res Toxicol
; 29(12): 2136-2144, 2016 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-27989146
11.
Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity.
Anal Bioanal Chem
; 408(5): 1425-43, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26753974
12.
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.
Arch Toxicol
; 90(12): 2979-3003, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27659300
13.
Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP).
Chem Res Toxicol
; 28(4): 711-21, 2015 Apr 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-25706813
14.
Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.
Chem Res Toxicol
; 27(12): 2071-81, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25372302
15.
Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Chem Res Toxicol
; 27(4): 576-86, 2014 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24552538
16.
Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.
Bioorg Med Chem
; 22(20): 5613-20, 2014 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24999003
17.
Towards automated binding affinity prediction using an iterative linear interaction energy approach.
Int J Mol Sci
; 15(1): 798-816, 2014 Jan 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24413750
18.
Characterization of human cytochrome P450s involved in the bioactivation of clozapine.
Drug Metab Dispos
; 41(3): 651-8, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23297297
19.
Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
Chem Res Toxicol
; 26(11): 1632-41, 2013 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-24083800
20.
Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity.
Biomarkers
; 18(1): 73-81, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23136842