Detalles de la búsqueda
1.
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Int J Mol Sci
; 24(11)2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298645
2.
Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology.
Handb Exp Pharmacol
; 260: 327-367, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31201557
3.
A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity.
J Pharmacol Exp Ther
; 361(1): 39-50, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28154014
4.
Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury.
Am J Physiol Renal Physiol
; 310(8): F705-F716, 2016 04 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26661656
5.
A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system.
bioRxiv
; 2024 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712135
6.
Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy.
bioRxiv
; 2024 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38712213
7.
Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.
Lab Chip
; 23(20): 4514-4527, 2023 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37766577
8.
A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies.
Metabolites
; 12(6)2022 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35736460
9.
Modeling oxidative injury response in human kidney organoids.
Stem Cell Res Ther
; 13(1): 76, 2022 02 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35189973
10.
Biofabrication of synthetic human liver tissue with advanced programmable functions.
iScience
; 25(12): 105503, 2022 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36404924
11.
Prediction of hepatic drug clearance with a human microfluidic four-cell liver acinus microphysiology system.
Toxicology
; 463: 152954, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34543702
12.
Human biomimetic liver microphysiology systems in drug development and precision medicine.
Nat Rev Gastroenterol Hepatol
; 18(4): 252-268, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33335282
13.
A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®.
Toxicology
; 450: 152667, 2021 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33359578
14.
Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS).
Toxicology
; 448: 152651, 2021 01 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-33307106
15.
Applications of the microphysiology systems database for experimental ADME-Tox and disease models.
Lab Chip
; 20(8): 1472-1492, 2020 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32211684
16.
Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
Cancer Res
; 67(9): 4390-8, 2007 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17483353
17.
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.
Nat Commun
; 10(1): 3126, 2019 07 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-31311938
18.
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Mol Cancer Ther
; 6(1): 269-76, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17237286
19.
A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX.
Lab Chip
; 18(17): 2614-2631, 2018 08 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30063238
20.
Author Correction: Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.
Nat Commun
; 14(1): 757, 2023 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36765087