Detalles de la búsqueda
1.
Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors.
Bioorg Med Chem
; 22(17): 4998-5012, 2014 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25009002
2.
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.
Bioorg Med Chem Lett
; 22(12): 3946-50, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22608961
3.
Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.
Bioorg Med Chem
; 18(19): 7113-20, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20817473
4.
Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.
ChemMedChem
; 15(7): 643-658, 2020 04 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-32003940
5.
Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models.
ACS Med Chem Lett
; 11(5): 754-759, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32435381
6.
Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1).
Bioorg Med Chem Lett
; 19(11): 2924-7, 2009 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19419866
7.
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.
Mol Cancer Ther
; 6(12 Pt 1): 3158-68, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18089710
8.
PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.
Clin Cancer Res
; 12(13): 4080-9, 2006 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16818708
9.
Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.
Future Med Chem
; 9(11): 1161-1174, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28722470
10.
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J Med Chem
; 60(5): 1693-1715, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28186757
11.
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.
J Med Chem
; 60(5): 1673-1692, 2017 03 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-28186755
12.
1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
J Med Chem
; 49(24): 7247-51, 2006 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17125279
13.
Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.
J Med Chem
; 59(4): 1501-17, 2016 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-26702542
14.
Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.
J Med Chem
; 48(8): 3080-4, 2005 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-15828847
15.
Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.
Eur J Med Chem
; 92: 377-86, 2015 Mar 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25585008
16.
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.
ACS Med Chem Lett
; 6(2): 173-7, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25699146
17.
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
Eur J Med Chem
; 94: 163-74, 2015 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25768700
18.
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
Eur J Med Chem
; 86: 352-63, 2014 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-25173853
19.
Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding.
J Med Chem
; 53(20): 7296-315, 2010 Oct 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-20873740
20.
Identification of N,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a potent, orally available cyclin dependent kinase inhibitor.
J Med Chem
; 52(16): 5152-63, 2009 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-19603809