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1.
Intracerebroventricular dosing of N-sulfoglucosamine sulfohydrolase in mucopolysaccharidosis IIIA mice reduces markers of brain lysosomal dysfunction.
J Biol Chem
; 298(12): 102625, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36306823
2.
Intermittent enzyme replacement therapy with recombinant human ß-galactosidase prevents neuraminidase 1 deficiency
J Biol Chem
; 295(39): 13556-13569, 2020 09 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-32727849
3.
Intracerebroventricular enzyme replacement therapy with ß-galactosidase reverses brain pathologies due to GM1 gangliosidosis in mice.
J Biol Chem
; 295(39): 13532-13555, 2020 09 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31481471
4.
Quantitative Assessment of Neuroinflammation, Myelinogenesis, Demyelination, and Nerve Fiber Regeneration in Immunostained Sciatic Nerves From Twitcher Mice With a Tissue Image Analysis Platform.
Toxicol Pathol
; 49(4): 950-962, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33691530
5.
Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB.
Proc Natl Acad Sci U S A
; 111(41): 14870-5, 2014 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-25267636
6.
Correction: Intermittent enzyme replacement therapy prevents Neu1 deficiency.
J Biol Chem
; 295(46): 15794, 2020 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33188082
7.
1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia.
Bioorg Med Chem Lett
; 21(3): 983-8, 2011 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21211973
8.
Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia.
Arterioscler Thromb Vasc Biol
; 29(9): 1265-70, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19667112
9.
Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.
Drug Deliv Transl Res
; 10(2): 425-439, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31942701
10.
Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization.
Thromb Res
; 122(4): 533-40, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18539312
11.
A novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) - part I: pharmacological characterization.
Thromb Haemost
; 97(1): 45-53, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17200770
12.
A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis.
Thromb Haemost
; 97(1): 54-61, 2007 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17200771
13.
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
Thromb Haemost
; 97(5): 847-55, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17479197
14.
Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice.
Mol Ther Methods Clin Dev
; 6: 43-53, 2017 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28664165
15.
Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis.
Circulation
; 111(17): 2219-26, 2005 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15851596
16.
Amplified anticoagulant activity of tissue factor-targeted thrombomodulin: in-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulin.
Thromb Haemost
; 96(3): 317-24, 2006 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-16953273
17.
Netrin-1 Interrupts Amyloid-ß Amplification, Increases sAßPPα in vitro and in vivo, and Improves Cognition in a Mouse Model of Alzheimer's Disease.
J Alzheimers Dis
; 52(1): 223-42, 2016 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27060954
18.
Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice.
Eur J Pharmacol
; 512(2-3): 215-22, 2005 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-15840407
19.
Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system.
Ultrasound Med Biol
; 31(6): 745-9, 2005 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-15936490
20.
P-selectin-targeting of the fibrin selective thrombolytic Desmodus rotundus salivary plasminogen activator alpha1.
Thromb Haemost
; 92(5): 956-65, 2004 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-15543321