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1.
The variability in beta-cell function in placebo-treated subjects with type 2 diabetes: application of the weight-HbA1c-insulin-glucose (WHIG) model.
Br J Clin Pharmacol
; 83(3): 487-497, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27679422
2.
Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid.
Br J Clin Pharmacol
; 81(6): 1113-23, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26852277
3.
Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid.
Pharm Res
; 33(4): 856-67, 2016 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-26626793
4.
Interplay between α-, ß-, and γ-secretases determines biphasic amyloid-ß protein level in the presence of a γ-secretase inhibitor.
J Biol Chem
; 288(2): 785-92, 2013 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23152503
5.
Population PKPD modeling of BACE1 inhibitor-induced reduction in Aß levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.
Pharm Res
; 31(3): 670-83, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24092053
6.
In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach.
Pharm Res
; 30(5): 1409-22, 2013 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23371514
7.
Systems pharmacology modeling of drug-induced modulation of thyroid hormones in dogs and translation to human.
Pharm Res
; 30(6): 1513-24, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23568527
8.
Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans.
Pharm Res
; 35(2): 26, 2018 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29368211
9.
Has inhibition of Aß production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data.
Eur J Clin Pharmacol
; 69(6): 1247-60, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23288352
10.
Building an adaptive dose simulation framework to aid dose and schedule selection.
CPT Pharmacometrics Syst Pharmacol
; 12(11): 1602-1618, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37574587
11.
Model-based meta-analysis of non-small cell lung cancer with standard of care PD-1 inhibitors and chemotherapy for early development decision making.
CPT Pharmacometrics Syst Pharmacol
; 12(11): 1751-1763, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-36642813
12.
Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI.
Eur J Neurosci
; 36(9): 3165-72, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22958226
13.
Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.
Pharm Res
; 28(7): 1561-76, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21347567
14.
A Model-Informed Drug Discovery and Development Strategy for the Novel Glucose-Responsive Insulin MK-2640 Enabled Rapid Decision Making.
Clin Pharmacol Ther
; 107(6): 1296-1311, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31889297
15.
Toward Progress in Quantitative Translational Medicine: A Call to Action.
Clin Pharmacol Ther
; 107(1): 85-88, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31750932
16.
Model-Informed Drug Discovery and Development: Current Industry Good Practice and Regulatory Expectations and Future Perspectives.
CPT Pharmacometrics Syst Pharmacol
; 8(2): 87-96, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30411538
17.
Clinical Evaluation of MK-2640: An Insulin Analog With Glucose-Responsive Properties.
Clin Pharmacol Ther
; 105(2): 417-425, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30125349
18.
Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.
Clin Pharmacol Ther
; 103(3): 378-383, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29330855
19.
Perspective on the State of Pharmacometrics and Systems Pharmacology Integration.
CPT Pharmacometrics Syst Pharmacol
; 7(10): 617-620, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29761892
20.
Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
J Pharmacol Toxicol Methods
; 56(2): 131-44, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17689270