Detalles de la búsqueda
1.
Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.
Int J Cancer
; 142(5): 968-975, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29055107
2.
Effects of altered expression and activity levels of CK1δ and É on tumor growth and survival of colorectal cancer patients.
Int J Cancer
; 136(12): 2799-810, 2015 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25404202
3.
The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance.
Cell Microbiol
; 15(7): 1198-211, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23320394
4.
Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels.
Antiviral Res
; 221: 105769, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38056603
5.
Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti-SARS-CoV-2 Activity.
ChemMedChem
; : e202400292, 2024 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38887198
6.
Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial.
Neurol Neuroimmunol Neuroinflamm
; 11(3): e200208, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38662979
7.
Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.
Clin Pharmacol Drug Dev
; 12(5): 525-534, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36938862
8.
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε.
Amino Acids
; 43(4): 1577-91, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22331384
9.
Safety and Efficacy of Vidofludimus Calcium in Patients Hospitalized with COVID-19: A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial.
Infect Dis Ther
; 11(6): 2159-2176, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36242741
10.
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
ACS Chem Biol
; 17(11): 3159-3168, 2022 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36318238
11.
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication.
iScience
; 25(5): 104293, 2022 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-35492218
12.
Discovery and hit-to-lead optimization of novel allosteric glucokinase activators.
Bioorg Med Chem Lett
; 21(18): 5417-22, 2011 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21813277
13.
Safety, Tolerability and Pharmacokinetics of Vidofludimus calcium (IMU-838) After Single and Multiple Ascending Oral Doses in Healthy Male Subjects.
Eur J Drug Metab Pharmacokinet
; 45(5): 557-573, 2020 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-32361977
14.
Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis.
Mult Scler Relat Disord
; 43: 102129, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32428844
15.
Clinical relevance of intestinal barrier dysfunction in common gastrointestinal diseases.
World J Gastrointest Pathophysiol
; 11(6): 114-130, 2020 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33362939
16.
Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro.
Viruses
; 12(8)2020 07 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-32751087
17.
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro.
Viruses
; 12(12)2020 12 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33291455
18.
The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study.
Drugs R D
; 19(4): 351-366, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31621054
19.
Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
Antiviral Res
; 143: 113-121, 2017 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28400201
20.
DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance.
Oncotarget
; 7(6): 7134-48, 2016 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26784250