Detalles de la búsqueda
1.
Catalytic in vivo protein knockdown by small-molecule PROTACs.
Nat Chem Biol
; 11(8): 611-7, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26075522
2.
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Bioorg Med Chem
; 23(21): 7000-6, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26455654
3.
Inhibition of Receptor-Interacting Protein Kinase 1 in Chronic Plaque Psoriasis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study.
Dermatol Ther (Heidelb)
; 14(2): 489-504, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38372938
4.
Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice.
Arthritis Rheum
; 62(10): 2973-83, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20583100
5.
Optimization of a Series of RIPK2 PROTACs.
J Med Chem
; 64(17): 12978-13003, 2021 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34432979
6.
Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.
J Pharm Sci
; 109(10): 3160-3171, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32565354
7.
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Commun Biol
; 3(1): 140, 2020 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32198438
8.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32551024
9.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ACS Med Chem Lett
; 10(11): 1518-1523, 2019 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31749904
10.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31265286
11.
N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.
J Pharmacol Exp Ther
; 326(2): 432-42, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18499743
12.
Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2.
J Pharmacol Exp Ther
; 326(2): 443-52, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18499744
13.
The Resting Potential and K+ Currents in Primary Human Articular Chondrocytes.
Front Physiol
; 9: 974, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30233381
14.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30344914
15.
Identification of an antibody-based immunoassay for measuring direct target binding of RIPK1 inhibitors in cells and tissues.
Pharmacol Res Perspect
; 5(6)2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29226625
16.
Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers.
Pharmacol Res Perspect
; 5(6)2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29226626
17.
Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells.
Bone
; 39(6): 1361-72, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16904389
18.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27109867
19.
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.
Cell Host Microbe
; 15(5): 623-35, 2014 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24746552
20.
Voltage-gated K+ currents in mouse articular chondrocytes regulate membrane potential.
Channels (Austin)
; 4(3): 179-91, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20372061