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1.
Phase 2 trial of bintrafusp alfa as second-line therapy for patients with locally advanced/metastatic biliary tract cancers.
Hepatology
; 78(3): 758-770, 2023 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36999533
2.
Avelumab in paediatric patients with refractory or relapsed solid tumours: dose-escalation results from an open-label, single-arm, phase 1/2 trial.
Cancer Immunol Immunother
; 71(10): 2485-2495, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35262780
3.
Phase I Study of the Bifunctional Fusion Protein Bintrafusp Alfa in Asian Patients with Advanced Solid Tumors, Including a Hepatocellular Carcinoma Safety-Assessment Cohort.
Oncologist
; 25(9): e1292-e1302, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32324927
4.
Tumor growth inhibition modeling in patients with second line biliary tract cancer and first line non-small cell lung cancer based on bintrafusp alfa trials.
CPT Pharmacometrics Syst Pharmacol
; 13(1): 143-153, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38087967
5.
Model-Informed Selection of the Recommended Phase III Dose of the Inhibitor of Apoptosis Protein Inhibitor, Xevinapant, in Combination with Cisplatin and Concurrent Radiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck.
Clin Pharmacol Ther
; 115(1): 52-61, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37777832
6.
Phase I Trial of First-line Bintrafusp Alfa in Patients with Locally Advanced or Persistent/Recurrent/Metastatic Cervical Cancer.
Clin Cancer Res
; 30(5): 975-983, 2024 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38165683
7.
Efficacy, safety, and biomarker analyses of bintrafusp alfa, a bifunctional fusion protein targeting TGF-ß and PD-L1, in patients with advanced non-small cell lung cancer.
J Immunother Cancer
; 12(3)2024 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38485188
8.
An IL-4/IL-13 dual antagonist reduces lung inflammation, airway hyperresponsiveness, and IgE production in mice.
Am J Respir Cell Mol Biol
; 49(1): 37-46, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23449738
9.
A multistate modeling and simulation framework to learn dose-response of oncology drugs: Application to bintrafusp alfa in non-small cell lung cancer.
CPT Pharmacometrics Syst Pharmacol
; 12(11): 1738-1750, 2023 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-37165943
10.
First-in-human phase Ib trial of M9241 (NHS-IL12) plus avelumab in patients with advanced solid tumors, including dose expansion in patients with advanced urothelial carcinoma.
J Immunother Cancer
; 11(5)2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37236636
11.
Bintrafusp Alfa Versus Pembrolizumab in Patients With Treatment-Naive, Programmed Death-Ligand 1-High Advanced NSCLC: A Randomized, Open-Label, Phase 3 Trial.
J Thorac Oncol
; 18(12): 1731-1742, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37597750
12.
Pharmacokinetic, biodistribution, and biophysical profiles of TNF nanobodies conjugated to linear or branched poly(ethylene glycol).
Bioconjug Chem
; 23(7): 1452-62, 2012 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-22731748
13.
Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors.
Clin Pharmacokinet
; 61(7): 985-995, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35484319
14.
Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach.
Clin Transl Sci
; 15(12): 2838-2843, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-36152313
15.
Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-ß and PD-L1.
Cancer Chemother Pharmacol
; 90(4): 369-379, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36066618
16.
Distinct in vitro binding properties of the anti-CD20 small modular immunopharmaceutical 2LM20-4 result in profound and sustained in vivo potency in cynomolgus monkeys.
Rheumatology (Oxford)
; 50(6): 1033-44, 2011 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-21258049
17.
Complex pharmacokinetics of a humanized antibody against human amyloid beta peptide, anti-abeta Ab2, in nonclinical species.
Pharm Res
; 28(7): 1696-706, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21424161
18.
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys.
J Transl Med
; 8: 41, 2010 Apr 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-20420683
19.
Characterizing Exposure-Response Relationship for Therapeutic Monoclonal Antibodies in Immuno-Oncology and Beyond: Challenges, Perspectives, and Prospects.
Clin Pharmacol Ther
; 108(6): 1156-1170, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32557643
20.
Selection of the Recommended Phase 2 Dose for Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-ß and PD-L1.
Clin Pharmacol Ther
; 108(3): 566-574, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31955412