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1.
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans.
Xenobiotica
; 51(11): 1255-1263, 2021 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-34461800
2.
Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Exp Cell Res
; 338(2): 251-60, 2015 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26302264
3.
Comparison of physiologic and pharmacologic parameters in Asian and mauritius cynomolgus macaques.
Regul Toxicol Pharmacol
; 73(1): 27-42, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26111605
4.
Evaluation of six proton pump inhibitors as inhibitors of various human cytochromes P450: focus on cytochrome P450 2C19.
Drug Metab Dispos
; 40(9): 1698-711, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22648560
5.
Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats.
Xenobiotica
; 42(11): 1058-68, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22574883
6.
BMS-813160: A Potent CCR2 and CCR5 Dual Antagonist Selected as a Clinical Candidate.
ACS Med Chem Lett
; 12(11): 1753-1758, 2021 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34795864
7.
Discovery of BMS-753426: A Potent Orally Bioavailable Antagonist of CC Chemokine Receptor 2.
ACS Med Chem Lett
; 12(6): 969-975, 2021 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34141082
8.
Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Drug Metab Dispos
; 38(1): 16-24, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19833845
9.
Hepatic disposition of the cytochrome P450 2E1 marker chlorzoxazone and its hydroxylated metabolite in isolated perfused rat livers.
J Pharm Sci
; 95(7): 1414-24, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16724323
10.
Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.
Bioanalysis
; 8(4): 265-74, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26807991
11.
Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.
Bioanalysis
; 8(15): 1611-1622, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27397670
12.
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
J Med Chem
; 58(3): 1556-62, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25584393
13.
Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.
ACS Med Chem Lett
; 6(8): 845-9, 2015 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288682
14.
Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.
ACS Med Chem Lett
; 6(7): 770-5, 2015 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-26191364
15.
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
ACS Med Chem Lett
; 6(8): 850-5, 2015 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288683
16.
Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.
Bioanalysis
; 6(13): 1795-811, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25157486
17.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 1: goals, properties of the PhRMA dataset, and comparison with literature datasets.
J Pharm Sci
; 100(10): 4050-73, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21523782
18.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution.
J Pharm Sci
; 100(10): 4074-89, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21452299
19.
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: prediction of plasma concentration-time profiles in human from in vivo preclinical data by using the Wajima approach.
J Pharm Sci
; 100(10): 4111-26, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21480234
20.
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: prediction of plasma concentration-time profiles in human by using the physiologically-based pharmacokinetic modeling approach.
J Pharm Sci
; 100(10): 4127-57, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21541937