Detalles de la búsqueda
1.
A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds.
Bioorg Chem
; 146: 107249, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38493638
2.
Discovery of novel tetrahydrobenzo[b]thiophene-3-carbonitriles as histone deacetylase inhibitors.
Bioorg Chem
; 110: 104801, 2021 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33756235
3.
Synthesis of 2-,4,-6-, and/or 7-substituted quinoline derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents: 3D QSAR-assisted design.
Bioorg Med Chem Lett
; 29(7): 917-922, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30738663
4.
Liquid phase combinatorial synthesis of 1,2,5-trisubstituted benzimidazole derivatives as human DHODH inhibitors.
Bioorg Chem
; 75: 118-126, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28941392
5.
Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.
Bioorg Chem
; 67: 130-8, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27376460
6.
A Patent Review of Human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors as Anticancer Agents and their Other Therapeutic Applications (1999-2022).
Recent Pat Anticancer Drug Discov
; 19(3): 280-297, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-37070439
7.
Recent advances on patents of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors as antimalarial agents.
Expert Opin Ther Pat
; 33(9): 579-596, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37942637
8.
Medicinal chemistry approaches for the discovery of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors as antimalarial agents.
Future Med Chem
; 15(14): 1295-1321, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37551689
9.
Structure-guided discovery of adenosine triphosphate-competitive casein kinase 2 inhibitors.
Future Med Chem
; 15(11): 987-1014, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37307219
10.
Hybrid Quantum Mechanics/Molecular Mechanics (QM/MM) Simulation: A Tool for Structure-Based Drug Design and Discovery.
Mini Rev Med Chem
; 22(8): 1096-1107, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-34620049
11.
Structure- and ligand-based drug design methods for the modeling of antimalarial agents: a review of updates from 2012 onwards.
J Biomol Struct Dyn
; 40(20): 10481-10506, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-34129805
12.
Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade.
J Pharm Anal
; 12(1): 15-28, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-35573874
13.
Integrated structure-guided computational design of novel substituted quinolizin-4-ones as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors.
Comput Biol Chem
; 101: 107787, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36401950
14.
Histone deacetylase 2: A potential therapeutic target for cancer and neurodegenerative disorders.
Eur J Med Chem
; 216: 113332, 2021 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33714914
15.
Design of 2-Nitroimidazooxazine Derivatives as Deazaflavin-Dependent Nitroreductase (Ddn) Activators as Anti-Mycobacterial Agents Based on 3D QSAR, HQSAR, and Docking Study with In Silico Prediction of Activity and Toxicity.
Interdiscip Sci
; 11(2): 191-205, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-28895050
16.
Medicinal Chemistry of Potassium Channel Modulators: An Update of Recent Progress (2011-2017).
Curr Med Chem
; 26(12): 2062-2084, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-29714134
17.
CoMFA, CoMSIA, Topomer CoMFA, HQSAR, molecular docking and molecular dynamics simulations study of triazine morpholino derivatives as mTOR inhibitors for the treatment of breast cancer.
Comput Biol Chem
; 80: 351-363, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-31085426
18.
3D QSAR-based design and liquid phase combinatorial synthesis of 1,2-disubstituted benzimidazole-5-carboxylic acid and 3-substituted-5H-benzimidazo[1,2-d][1,4]benzodiazepin-6(7H)-one derivatives as anti-mycobacterial agents.
Medchemcomm
; 10(5): 817-827, 2019 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31293724
19.
Combined in silico approaches for the identification of novel inhibitors of human islet amyloid polypeptide (hIAPP) fibrillation.
J Mol Graph Model
; 77: 295-310, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28917147
20.
Molecular modeling study for the design of novel acetyl-CoA carboxylase inhibitors using 3D QSAR, molecular docking and dynamic simulations.
J Biomol Struct Dyn
; 35(9): 2003-2015, 2017 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-27335214