Detalles de la búsqueda
1.
Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics.
Bioconjug Chem
; 24(4): 640-7, 2013 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-23496378
2.
Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.
Bioorg Med Chem Lett
; 22(7): 2613-9, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22365762
3.
Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
Bioorg Med Chem Lett
; 22(7): 2609-12, 2012 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22374217
4.
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Bioorg Med Chem Lett
; 19(4): 1240-4, 2009 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19155174
5.
Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Arch Biochem Biophys
; 469(2): 220-31, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17999913
6.
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
J Med Chem
; 46(14): 2973-84, 2003 Jul 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-12825937
7.
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J Med Chem
; 45(12): 2388-409, 2002 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-12036349
8.
An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents.
Int J Pharm
; 466(1-2): 58-67, 2014 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24607208
9.
Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
J Control Release
; 183: 124-37, 2014 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24657948
10.
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
J Med Chem
; 51(14): 4239-52, 2008 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-18578472
11.
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Bioorg Med Chem Lett
; 17(10): 2697-702, 2007 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17395460
12.
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(19): 5390-5, 2007 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17761419
13.
Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.
Bioorg Med Chem Lett
; 17(21): 5989-94, 2007 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17804227
14.
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(20): 5677-82, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17766111
15.
Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Bioorg Med Chem Lett
; 17(22): 6280-5, 2007 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17900896
16.
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(20): 5671-6, 2007 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17804233
17.
Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 16(7): 1775-9, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16439123
18.
Kinesin spindle protein (KSP) inhibitors. Part 4: Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 16(12): 3175-9, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16603356
19.
Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility.
Bioorg Med Chem Lett
; 16(7): 1780-3, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16439122
20.
3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.
Bioorg Med Chem Lett
; 16(23): 6049-53, 2006 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16978863