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1.
Exploring the potential of dried plasma collection cards for liquid chromatography coupled with tandem mass spectrometry quantitation of giredestrant in human plasma.
Biomed Chromatogr
; 37(3): e5554, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36417291
2.
A phase 1, randomized study to evaluate safety, tolerability, and pharmacokinetics of GDC-3280, a potential novel anti-fibrotic small molecule, in healthy subjects.
Pulm Pharmacol Ther
; 69: 102051, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34166834
3.
A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.
Drug Metab Dispos
; 47(5): 547-555, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30858239
4.
Replication studies of carboxymethylated DNA lesions in human cells.
Nucleic Acids Res
; 45(12): 7276-7284, 2017 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-28531304
5.
Determination of a novel antifibrotic small molecule GDC-3280 in human plasma and urine by liquid chromatography tandem mass spectrometry to support its first-in-human clinical trial.
Biomed Chromatogr
; 33(4): e4482, 2019 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-30618197
6.
Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.
Pharm Res
; 34(11): 2403-2414, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28815392
7.
Transcriptional inhibition and mutagenesis induced by N-nitroso compound-derived carboxymethylated thymidine adducts in DNA.
Nucleic Acids Res
; 43(2): 1012-8, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25572317
8.
Quantification of Azaserine-Induced Carboxymethylated and Methylated DNA Lesions in Cells by Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.
Anal Chem
; 88(16): 8036-42, 2016 08 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-27441891
9.
Translesion synthesis of 8,5'-cyclopurine-2'-deoxynucleosides by DNA polymerases η, ι, and ζ.
J Biol Chem
; 288(40): 28548-56, 2013 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-23965998
10.
A quantitative assay for assessing the effects of DNA lesions on transcription.
Nat Chem Biol
; 8(10): 817-22, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22902614
11.
High-throughput analysis of the mutagenic and cytotoxic properties of DNA lesions by next-generation sequencing.
Nucleic Acids Res
; 39(14): 5945-54, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21470959
12.
Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer.
Cancer Res Commun
; 3(12): 2551-2559, 2023 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38019116
13.
Accurate and efficient bypass of 8,5'-cyclopurine-2'-deoxynucleosides by human and yeast DNA polymerase η.
Chem Res Toxicol
; 25(8): 1682-91, 2012 Aug 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-22768970
14.
In-vitro replication studies on O(2)-methylthymidine and O(4)-methylthymidine.
Chem Res Toxicol
; 25(11): 2523-31, 2012 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-23113558
15.
Synthesis and characterization of oligodeoxyribonucleotides containing a site-specifically incorporated N6-carboxymethyl-2'-deoxyadenosine or N4-carboxymethyl-2'-deoxycytidine.
Nucleic Acids Res
; 38(19): 6774-84, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20507914
16.
Volumetric absorptive microsampling-LC-MS/MS assays for quantitation of giredestrant in dried human whole blood.
Bioanalysis
; 14(21): 1377-1389, 2022 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-36655682
17.
Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function.
J Clin Pharmacol
; 62(2): 171-181, 2022 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-34402068
18.
In vitro replication studies of carboxymethylated DNA lesions with Saccharomyces cerevisiae polymerase η.
Biochemistry
; 50(35): 7666-73, 2011 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-21809836
19.
Chemical synthesis of oligodeoxyribonucleotides containing N3- and O4-carboxymethylthymidine and their formation in DNA.
Nucleic Acids Res
; 37(2): 336-45, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19042973
20.
Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery.
J Pharm Biomed Anal
; 164: 62-69, 2019 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30359840