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1.
Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach.
Antimicrob Agents Chemother
; : e0032824, 2024 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38842325
2.
Quantification of Neonatal Fc Receptor and Beta-2 Microglobulin in Human Liver Tissues by Ultraperformance Liquid Chromatography-Multiple Reaction Monitoring-based Targeted Quantitative Proteomics for Applications in Biotherapeutic Physiologically-based Pharmacokinetic Models.
Drug Metab Dispos
; 48(10): 925-933, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32723849
3.
Minimal Cerebrospinal Fluid Concentration of Miltefosine despite Therapeutic Plasma Levels during the Treatment of Amebic Encephalitis.
Antimicrob Agents Chemother
; 64(1)2019 12 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-31685474
4.
Antileishmanial Efficacy and Pharmacokinetics of DB766-Azole Combinations.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29061761
5.
Cytochrome P450 and flavin-containing monooxygenase families: age-dependent differences in expression and functional activity.
Pediatr Res
; 83(2): 527-535, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28922349
6.
Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny.
Drug Metab Dispos
; 44(7): 975-83, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-26839369
7.
Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents.
Bioorg Med Chem Lett
; 26(10): 2551-2556, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27048943
8.
Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.
Bioorg Med Chem
; 24(11): 2451-65, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27102161
9.
Ethnic variability in the expression of hepatic drug transporters: absolute quantification by an optimized targeted quantitative proteomic approach.
Drug Metab Dispos
; 43(7): 1045-55, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25926430
10.
SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines.
Bioorg Med Chem
; 23(16): 5182-9, 2015 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25749014
11.
A simple and sensitive assay for eflornithine quantification in rat brain using pre-column derivatization and UPLC-MS/MS detection.
Biomed Chromatogr
; 29(6): 918-24, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25365958
12.
Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.
Antimicrob Agents Chemother
; 58(7): 4064-74, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24798280
13.
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
Antimicrob Agents Chemother
; 58(8): 4452-63, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24867978
14.
The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics.
Drug Metab Dispos
; 42(8): 1241-51, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24816681
15.
Pharmacogenomics education strategies in the United States pharmacy school curricula.
Curr Pharm Teach Learn
; 16(3): 221-230, 2024 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38281827
16.
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.
Antimicrob Agents Chemother
; 57(11): 5330-43, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23959303
17.
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Bioorg Med Chem
; 21(21): 6732-41, 2013 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24012380
18.
CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles.
Res Sq
; 2023 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37546914
19.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
Antimicrob Agents Chemother
; 56(7): 3690-9, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22508306
20.
Development of a UPLC-MRM-based targeted proteomic method to profile subcellular organelle marker proteins from human liver tissues.
Sci Rep
; 12(1): 10985, 2022 06 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-35768540