Detalles de la búsqueda
1.
Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1.
Bioorg Med Chem
; 27(7): 1232-1245, 2019 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30777661
2.
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors.
Bioorg Med Chem
; 27(5): 822-831, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30718063
3.
Application of the concept of oxime library screening by mass spectrometry (MS) binding assays to pyrrolidine-3-carboxylic acid derivatives as potential inhibitors of γ-aminobutyric acid transporter 1 (GAT1).
Bioorg Med Chem
; 27(13): 2753-2763, 2019 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31097402
4.
Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4.
Bioorg Med Chem
; 27(1): 144-152, 2019 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30503411
5.
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors.
Bioorg Med Chem
; 26(22): 5944-5961, 2018 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30442505
6.
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors.
Bioorg Med Chem
; 26(12): 3668-3687, 2018 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29886082
7.
Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET.
Biomed Chromatogr
; 32(7): e4231, 2018 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-29500932
8.
The Environment Shapes the Inner Vestibule of LeuT.
PLoS Comput Biol
; 12(11): e1005197, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27835643
9.
Synthesis of Allene Substituted Nipecotic Acids by Allenylation of Terminal Alkynes.
J Org Chem
; 82(16): 8371-8388, 2017 08 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28699342
10.
Determination of the enantiomeric purity of the selective dopamine transporter inhibitor (+)-R,R-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol.
Chirality
; 29(6): 294-303, 2017 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-28437017
11.
Determination of enantiomeric excess of nipecotic acid as 1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl) derivatives.
Chirality
; 29(1): 48-56, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28019695
12.
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.
Bioorg Med Chem
; 24(9): 2072-96, 2016 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27039250
13.
Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids.
Bioorg Med Chem
; 23(6): 1284-306, 2015 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25698617
14.
Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays.
Anal Bioanal Chem
; 407(2): 471-85, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25450050
15.
MS transport assays for γ-aminobutyric acid transporters--an efficient alternative for radiometric assays.
Anal Chem
; 86(15): 7575-83, 2014 Aug 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-25007119
16.
Screening for new ligands of the MB327-PAM-1 binding site of the nicotinic acetylcholine receptor.
Toxicol Lett
; 394: 23-31, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38387764
17.
MS Binding Assays with UNC0642 as reporter ligand for the MB327 binding site of the nicotinic acetylcholine receptor.
Toxicol Lett
; 392: 94-106, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38216073
18.
Identification of ligands binding to MB327-PAM-1, a binding pocket relevant for resensitization of nAChRs.
Toxicol Lett
; 398: 91-104, 2024 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38768836
19.
Synthesis and biological evaluation of novel MB327 analogs as resensitizers for desensitized nicotinic acetylcholine receptors after intoxication with nerve agents.
Toxicol Lett
; 397: 151-162, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38759939
20.
Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.
J Biol Chem
; 287(42): 35733-35746, 2012 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22896705