Detalles de la búsqueda
1.
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies.
Bioorg Med Chem Lett
; 26(12): 2920-2926, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27158141
2.
Anilinoquinazoline inhibitors of the RET kinase domain-Elaboration of the 7-position.
Bioorg Med Chem Lett
; 26(11): 2724-9, 2016 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27086121
3.
Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer.
Proc Natl Acad Sci U S A
; 110(30): 12426-31, 2013 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-23836671
4.
A reversed sulfonamide series of selective RORc inverse agonists.
Bioorg Med Chem Lett
; 24(24): 5769-5776, 2014 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25453817
5.
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.
Arthritis Rheum
; 65(8): 2161-71, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23666743
6.
Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Bioorg Med Chem Lett
; 23(5): 1238-44, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23374866
7.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett
; 23(12): 3592-8, 2013 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23642482
8.
Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Bioorg Med Chem Lett
; 22(13): 4296-302, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22672799
9.
Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RETV804M Kinase.
ACS Med Chem Lett
; 11(4): 497-505, 2020 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32292556
10.
Towards improving compound selection in structure-based virtual screening.
Drug Discov Today
; 13(5-6): 219-26, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18342797
11.
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia.
Cell Rep
; 22(13): 3641-3659, 2018 03 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-29590629
12.
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
J Med Chem
; 61(23): 10767-10792, 2018 12 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30403352
13.
Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade.
F1000Res
; 5: 1005, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27429741
14.
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
ACS Chem Biol
; 11(11): 3179-3190, 2016 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27689388
15.
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
J Med Chem
; 59(24): 11120-11137, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28002956
16.
The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity.
Eur J Med Chem
; 112: 20-32, 2016 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26874741
17.
Structure-based approaches to drug design and virtual screening.
Curr Opin Drug Discov Devel
; 5(3): 407-13, 2002 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12058616
18.
PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.
J Med Chem
; 45(6): 1221-32, 2002 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-11881991
19.
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
J Med Chem
; 56(16): 6352-70, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23859074
20.
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
J Med Chem
; 55(12): 5901-21, 2012 Jun 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-22591402