Búsqueda | Biblioteca Virtual en Salud

1.

A combinatorial approach for achieving CNS-selective RNAi.

Ferguson, Chantal M; Godinho, Bruno M D C; Echeverria, Dimas; Hassler, Matthew; Vangjeli, Lorenc; Sousa, Jacquelyn; McHugh, Nicholas; Alterman, Julia; Hariharan, Vignesh; Krishnamurthy, Pranathi Meda; Watts, Jonathan; Rogaev, Eveny; Khvorova, Anastasia.

Nucleic Acids Res ; 52(9): 5273-5284, 2024 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-38348876

2.

Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.

Sarli, Samantha L; Fakih, Hassan H; Kelly, Karen; Devi, Gitali; Rembetsy-Brown, Julia M; McEachern, Holly R; Ferguson, Chantal M; Echeverria, Dimas; Lee, Jonathan; Sousa, Jacquelyn; Sleiman, Hanadi F; Khvorova, Anastasia; Watts, Jonathan K.

Nucleic Acids Res ; 52(9): 4799-4817, 2024 May 22.

Artículo en Inglés | MEDLINE | ID: mdl-38613388

3.

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.

Zhang, Han; Kelly, Karen; Lee, Jonathan; Echeverria, Dimas; Cooper, David; Panwala, Rebecca; Amrani, Nadia; Chen, Zexiang; Gaston, Nicholas; Wagh, Atish; Newby, Gregory A; Xie, Jun; Liu, David R; Gao, Guangping; Wolfe, Scot A; Khvorova, Anastasia; Watts, Jonathan K; Sontheimer, Erik J.

Nucleic Acids Res ; 52(2): 977-997, 2024 Jan 25.

Artículo en Inglés | MEDLINE | ID: mdl-38033325

4.

Antisense oligonucleotide rescue of CGG expansion-dependent FMR1 mis-splicing in fragile X syndrome restores FMRP.

Shah, Sneha; Sharp, Kevin J; Raju Ponny, Sithara; Lee, Jonathan; Watts, Jonathan K; Berry-Kravis, Elizabeth; Richter, Joel D.

Proc Natl Acad Sci U S A ; 120(27): e2302534120, 2023 07 04.

Artículo en Inglés | MEDLINE | ID: mdl-37364131

5.

Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.

Hariharan, Vignesh N; Shin, Minwook; Chang, Ching-Wen; O'Reilly, Daniel; Biscans, Annabelle; Yamada, Ken; Guo, Zhiru; Somasundaran, Mohan; Tang, Qi; Monopoli, Kathryn; Krishnamurthy, Pranathi Meda; Devi, Gitali; McHugh, Nicholas; Cooper, David A; Echeverria, Dimas; Cruz, John; Chan, Io Long; Liu, Ping; Lim, Sun-Young; McConnell, Jill; Singh, Satya Prakash; Hildebrand, Samuel; Sousa, Jacquelyn; Davis, Sarah M; Kennedy, Zachary; Ferguson, Chantal; Godinho, Bruno M D C; Thillier, Yann; Caiazzi, Jillian; Ly, Socheata; Muhuri, Manish; Kelly, Karen; Humphries, Fiachra; Cousineau, Alyssa; Parsi, Krishna Mohan; Li, Qi; Wang, Yang; Maehr, René; Gao, Guangping; Korkin, Dmitry; McDougall, William M; Finberg, Robert W; Fitzgerald, Katherine A; Wang, Jennifer P; Watts, Jonathan K; Khvorova, Anastasia.

Proc Natl Acad Sci U S A ; 120(11): e2219523120, 2023 03 14.

Artículo en Inglés | MEDLINE | ID: mdl-36893269

6.

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors.

Hildebrand, Samuel R; Hedger, Adam K; Yamada, Ken; Watts, Jonathan K; Khvorova, Anastasia.

RNA ; 29(7): 1077-1083, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-37059467

7.

G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.

Wang, Feng; Calvo-Roitberg, Ezequiel; Rembetsy-Brown, Julia M; Fang, Minggang; Sousa, Jacquelyn; Kartje, Zachary J; Krishnamurthy, Pranathi Meda; Lee, Jonathan; Green, Michael R; Pai, Athma A; Watts, Jonathan K.

Nucleic Acids Res ; 50(22): 12657-12673, 2022 12 09.

Artículo en Inglés | MEDLINE | ID: mdl-36511872

8.

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.

Shin, Minwook; Chan, Io Long; Cao, Yuming; Gruntman, Alisha M; Lee, Jonathan; Sousa, Jacquelyn; Rodríguez, Tomás C; Echeverria, Dimas; Devi, Gitali; Debacker, Alexandre J; Moazami, Michael P; Krishnamurthy, Pranathi Meda; Rembetsy-Brown, Julia M; Kelly, Karen; Yukselen, Onur; Donnard, Elisa; Parsons, Teagan J; Khvorova, Anastasia; Sontheimer, Erik J; Maehr, René; Garber, Manuel; Watts, Jonathan K.

Nucleic Acids Res ; 50(15): 8418-8430, 2022 08 26.

Artículo en Inglés | MEDLINE | ID: mdl-35920332

9.

Detecting chromatin interactions between and along sister chromatids with SisterC.

Oomen, Marlies E; Hedger, Adam K; Watts, Jonathan K; Dekker, Job.

Nat Methods ; 17(10): 1002-1009, 2020 10.

Artículo en Inglés | MEDLINE | ID: mdl-32968250

10.

Double Click: Unexpected 1:2 Stoichiometry in a Norbornene-Tetrazine Reaction.

Devi, Gitali; Hedger, Adam K; Whitby, Richard J; Watts, Jonathan K.

J Org Chem ; 88(9): 5341-5347, 2023 May 05.

Artículo en Inglés | MEDLINE | ID: mdl-37058436

11.

Enhancer RNA facilitates NELF release from immediate early genes.

Schaukowitch, Katie; Joo, Jae-Yeol; Liu, Xihui; Watts, Jonathan K; Martinez, Carlos; Kim, Tae-Kyung.

Mol Cell ; 56(1): 29-42, 2014 Oct 02.

Artículo en Inglés | MEDLINE | ID: mdl-25263592

12.

An Investigation into the Potential of Targeting Escherichia coli rne mRNA with Locked Nucleic Acid (LNA) Gapmers as an Antibacterial Strategy.

Goddard, Layla R; Mardle, Charlotte E; Gneid, Hassan; Ball, Ciara G; Gowers, Darren M; Atkins, Helen S; Butt, Louise E; Watts, Jonathan K; Vincent, Helen A; Callaghan, Anastasia J.

Molecules ; 26(11)2021 Jun 04.

Artículo en Inglés | MEDLINE | ID: mdl-34200016

13.

Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs' dystrophy.

Hu, Jiaxin; Rong, Ziye; Gong, Xin; Zhou, Zhengyang; Sharma, Vivek K; Xing, Chao; Watts, Jonathan K; Corey, David R; Mootha, V Vinod.

Hum Mol Genet ; 27(6): 1015-1026, 2018 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-29325021

14.

Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-Quadruplexes.

Price, David A; Kartje, Zachary J; Hughes, Joanna A; Hill, Tayler D; Loth, Taylor M; Watts, Jonathan K; Gagnon, Keith T; Moran, Sean D.

Chembiochem ; 21(19): 2792-2804, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-32372560

15.

Next-Generation Peptide Nucleic Acid Chimeras Exhibit High Affinity and Potent Gene Silencing.

Debacker, Alexandre J; Sharma, Vivek K; Meda Krishnamurthy, Pranathi; O'Reilly, Daniel; Greenhill, Rachel; Watts, Jonathan K.

Biochemistry ; 58(6): 582-589, 2019 02 12.

Artículo en Inglés | MEDLINE | ID: mdl-30520300

16.

Health emergency over Brazil's Yanomami people.

Watts, Jonathan.

Lancet ; 401(10377): 631, 2023 02 25.

Artículo en Inglés | MEDLINE | ID: mdl-36842435

17.

Healing the Amazon.

Watts, Jonathan.

Lancet ; 399(10337): 1767-1768, 2022 05 07.

Artículo en Inglés | MEDLINE | ID: mdl-35526543

18.

Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo.

Sharma, Vivek K; Osborn, Maire F; Hassler, Matthew R; Echeverria, Dimas; Ly, Socheata; Ulashchik, Egor A; Martynenko-Makaev, Yury V; Shmanai, Vadim V; Zatsepin, Timofei S; Khvorova, Anastasia; Watts, Jonathan K.

Bioconjug Chem ; 29(7): 2478-2488, 2018 07 18.

Artículo en Inglés | MEDLINE | ID: mdl-29898368

19.

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation.

Miller, Rachael; Paquette, Joseph; Barker, Alexandra; Sapp, Ellen; McHugh, Nicholas; Bramato, Brianna; Yamada, Nazomi; Alterman, Julia; Echeveria, Dimas; Yamada, Ken; Watts, Jonathan K; Anaclet, Christelle; DiFiglia, Marian; Khvorova, Anastasia; Aronin, Neil.

bioRxiv ; 2024 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-38895198

20.

EZH2 inhibition reactivates epigenetically silenced FMR1 and normalizes molecular and electrophysiological abnormalities in fragile X syndrome neurons.

Fang, Minggang; Deibler, Sara K; Krishnamurthy, Pranathi Meda; Wang, Feng; Rodriguez, Paola; Banday, Shahid; Virbasius, Ching-Man; Sena-Esteves, Miguel; Watts, Jonathan K; Green, Michael R.

Front Neurosci ; 18: 1348478, 2024.

Artículo en Inglés | MEDLINE | ID: mdl-38449737

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