Detalles de la búsqueda
1.
Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy.
Cancer Gene Ther
; 13(8): 771-9, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16543915
2.
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Cancer Res
; 60(14): 3761-9, 2000 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-10919648
3.
Cyclophosphamide modulates rat hepatic cytochrome P450 2C11 and steroid 5 alpha-reductase activity and messenger RNA levels through the combined action of acrolein and phosphoramide mustard.
Cancer Res
; 53(11): 2490-7, 1993 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-8495410
4.
Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy.
Cancer Res
; 55(3): 581-9, 1995 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-7834628
5.
N,N',N''-triethylenethiophosphoramide (thio-TEPA) oxygenation by constitutive hepatic P450 enzymes and modulation of drug metabolism and clearance in vivo by P450-inducing agents.
Cancer Res
; 51(9): 2340-5, 1991 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-1707751
6.
Mechanisms of cyclophosphamide action on hepatic P-450 expression.
Cancer Res
; 50(18): 5720-6, 1990 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-2118418
7.
Biotransformation of N,N',N''-triethylenethiophosphoramide: oxidative desulfuration to yield N,N',N''-triethylenephosphoramide associated with suicide inactivation of a phenobarbital-inducible hepatic P-450 monooxygenase.
Cancer Res
; 50(3): 464-71, 1990 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-2105156
8.
Oxidative metabolism of cyclophosphamide: identification of the hepatic monooxygenase catalysts of drug activation.
Cancer Res
; 49(9): 2344-50, 1989 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-2706622
9.
Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy.
Cancer Res
; 61(11): 4437-44, 2001 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-11389073
10.
Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene.
Cancer Res
; 57(21): 4830-7, 1997 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-9354446
11.
Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
Cancer Res
; 58(19): 4391-401, 1998 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-9766669
12.
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
Cancer Res
; 53(23): 5629-37, 1993 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-8242617
13.
Gene-specific oligonucleotide probes for alpha, mu, pi, and microsomal rat glutathione S-transferases: analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs.
Cancer Res
; 52(20): 5797-802, 1992 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-1394205
14.
Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats.
Cancer Res
; 52(3): 540-7, 1992 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-1732040
15.
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
Cancer Res
; 57(10): 1946-54, 1997 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-9157990
16.
Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.
Cancer Res
; 56(6): 1331-40, 1996 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-8640822
17.
Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolite in rats.
Cancer Res
; 54(11): 2878-86, 1994 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-8187072
18.
Evidence for enzymatic activation and oxygen involvement in cytotoxicity and antitumor activity of N,N',N''-triethylenethiophosphoramide.
Cancer Res
; 49(18): 4996-5001, 1989 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-2504483
19.
Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells.
Diabetes
; 49(12): 2012-20, 2000 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-11118002
20.
Hepatic P450 expression in hypothyroid rats: differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone.
Mol Endocrinol
; 5(1): 13-20, 1991 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-2017188