Búsqueda | Biblioteca Virtual en Salud

1.

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Johannessen, Cory M; Boehm, Jesse S; Kim, So Young; Thomas, Sapana R; Wardwell, Leslie; Johnson, Laura A; Emery, Caroline M; Stransky, Nicolas; Cogdill, Alexandria P; Barretina, Jordi; Caponigro, Giordano; Hieronymus, Haley; Murray, Ryan R; Salehi-Ashtiani, Kourosh; Hill, David E; Vidal, Marc; Zhao, Jean J; Yang, Xiaoping; Alkan, Ozan; Kim, Sungjoon; Harris, Jennifer L; Wilson, Christopher J; Myer, Vic E; Finan, Peter M; Root, David E; Roberts, Thomas M; Golub, Todd; Flaherty, Keith T; Dummer, Reinhard; Weber, Barbara L; Sellers, William R; Schlegel, Robert; Wargo, Jennifer A; Hahn, William C; Garraway, Levi A.

Nature ; 468(7326): 968-72, 2010 Dec 16.

Artículo en Inglés | MEDLINE | ID: mdl-21107320

2.

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

Maxwell, Christopher A; Benítez, Javier; Gómez-Baldó, Laia; Osorio, Ana; Bonifaci, Núria; Fernández-Ramires, Ricardo; Costes, Sylvain V; Guinó, Elisabet; Chen, Helen; Evans, Gareth J R; Mohan, Pooja; Català, Isabel; Petit, Anna; Aguilar, Helena; Villanueva, Alberto; Aytes, Alvaro; Serra-Musach, Jordi; Rennert, Gad; Lejbkowicz, Flavio; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Ripamonti, Carla B; Bonanni, Bernardo; Viel, Alessandra; Allavena, Anna; Bernard, Loris; Radice, Paolo; Friedman, Eitan; Kaufman, Bella; Laitman, Yael; Dubrovsky, Maya; Milgrom, Roni; Jakubowska, Anna; Cybulski, Cezary; Gorski, Bohdan; Jaworska, Katarzyna; Durda, Katarzyna; Sukiennicki, Grzegorz; Lubinski, Jan; Shugart, Yin Yao; Domchek, Susan M; Letrero, Richard; Weber, Barbara L; Hogervorst, Frans B L; Rookus, Matti A; Collee, J Margriet; Devilee, Peter; Ligtenberg, Marjolijn J; Luijt, Rob B van der.

PLoS Biol ; 9(11): e1001199, 2011 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-22110403

3.

Patterns of somatic mutation in human cancer genomes.

Greenman, Christopher; Stephens, Philip; Smith, Raffaella; Dalgliesh, Gillian L; Hunter, Christopher; Bignell, Graham; Davies, Helen; Teague, Jon; Butler, Adam; Stevens, Claire; Edkins, Sarah; O'Meara, Sarah; Vastrik, Imre; Schmidt, Esther E; Avis, Tim; Barthorpe, Syd; Bhamra, Gurpreet; Buck, Gemma; Choudhury, Bhudipa; Clements, Jody; Cole, Jennifer; Dicks, Ed; Forbes, Simon; Gray, Kris; Halliday, Kelly; Harrison, Rachel; Hills, Katy; Hinton, Jon; Jenkinson, Andy; Jones, David; Menzies, Andy; Mironenko, Tatiana; Perry, Janet; Raine, Keiran; Richardson, Dave; Shepherd, Rebecca; Small, Alexandra; Tofts, Calli; Varian, Jennifer; Webb, Tony; West, Sofie; Widaa, Sara; Yates, Andy; Cahill, Daniel P; Louis, David N; Goldstraw, Peter; Nicholson, Andrew G; Brasseur, Francis; Looijenga, Leendert; Weber, Barbara L.

Nature ; 446(7132): 153-8, 2007 Mar 08.

Artículo en Inglés | MEDLINE | ID: mdl-17344846

4.

Cancer genomics.

Weber, Barbara L.

Cancer Cell ; 1(1): 37-47, 2002 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-12086886

5.

Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome.

Huang, Jia; Zhang, Lin; Greshock, Joel; Colligon, Theresa A; Wang, Yan; Ward, Renee; Katsaros, Dionyssios; Lassus, Heini; Butzow, Ralf; Godwin, Andrew K; Testa, Joseph R; Nathanson, Katherine L; Gimotty, Phyllis A; Coukos, George; Weber, Barbara L; Degenhardt, Yan.

Genes Chromosomes Cancer ; 50(8): 606-18, 2011 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-21563232

6.

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer.

Zhang, Lin; Volinia, Stefano; Bonome, Tomas; Calin, George Adrian; Greshock, Joel; Yang, Nuo; Liu, Chang-Gong; Giannakakis, Antonis; Alexiou, Pangiotis; Hasegawa, Kosei; Johnstone, Cameron N; Megraw, Molly S; Adams, Sarah; Lassus, Heini; Huang, Jia; Kaur, Sippy; Liang, Shun; Sethupathy, Praveen; Leminen, Arto; Simossis, Victor A; Sandaltzopoulos, Raphael; Naomoto, Yoshio; Katsaros, Dionyssios; Gimotty, Phyllis A; DeMichele, Angela; Huang, Qihong; Bützow, Ralf; Rustgi, Anil K; Weber, Barbara L; Birrer, Michael J; Hatzigeorgiou, Artemis G; Croce, Carlo M; Coukos, George.

Proc Natl Acad Sci U S A ; 105(19): 7004-9, 2008 May 13.

Artículo en Inglés | MEDLINE | ID: mdl-18458333

7.

Optimizing the Therapeutic Window of Targeted Drugs in Oncology: Potency-Guided First-in-Human Studies.

Goldstein, Matthew J; Peters, Malte; Weber, Barbara L; Davis, Charles B.

Clin Transl Sci ; 14(2): 536-543, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33048459

8.

A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel.

Flaherty, Keith T; Schiller, Joan; Schuchter, Lynn M; Liu, Glenn; Tuveson, David A; Redlinger, Maryann; Lathia, Chetan; Xia, Chenghua; Petrenciuc, Oana; Hingorani, Sunil R; Jacobetz, Michael A; Van Belle, Patricia A; Elder, David; Brose, Marcia S; Weber, Barbara L; Albertini, Mark R; O'Dwyer, Peter J.

Clin Cancer Res ; 14(15): 4836-42, 2008 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-18676756

9.

Cancer cell lines as genetic models of their parent histology: analyses based on array comparative genomic hybridization.

Greshock, Joel; Nathanson, Katherine; Martin, Anne-Marie; Zhang, Lin; Coukos, George; Weber, Barbara L; Zaks, Tal Z.

Cancer Res ; 67(8): 3594-600, 2007 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-17440070

10.

Genome-wide DNA copy number predictors of lapatinib sensitivity in tumor-derived cell lines.

Greshock, Joel; Cheng, Jie; Rusnak, David; Martin, Anne Marie; Wooster, Richard; Gilmer, Tona; Lee, Kwan; Weber, Barbara L; Zaks, Tal.

Mol Cancer Ther ; 7(4): 935-43, 2008 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-18413807

11.

Integrative genomic analysis of phosphatidylinositol 3'-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer.

Zhang, Lin; Huang, Jia; Yang, Nuo; Greshock, Joel; Liang, Shun; Hasegawa, Kosei; Giannakakis, Antonis; Poulos, Nikolaos; O'Brien-Jenkins, Ann; Katsaros, Dionyssios; Butzow, Ralf; Weber, Barbara L; Coukos, George.

Clin Cancer Res ; 13(18 Pt 1): 5314-21, 2007 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-17875760

12.

Estrogen receptor status could modulate the genomic pattern in familial and sporadic breast cancer.

Melchor, Lorenzo; Honrado, Emiliano; Huang, Jia; Alvarez, Sara; Naylor, Tara L; García, María J; Osorio, Ana; Blesa, David; Stratton, Michael R; Weber, Barbara L; Cigudosa, Juan C; Rahman, Nazneen; Nathanson, Katherine L; Benítez, Javier.

Clin Cancer Res ; 13(24): 7305-13, 2007 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-18094411

13.

Factors determining dissemination of results and uptake of genetic testing in families with known BRCA1/2 mutations.

Finlay, Esme; Stopfer, Jill E; Burlingame, Eric; Evans, Katherine Goldfeder; Nathanson, Katherine L; Weber, Barbara L; Armstrong, Katrina; Rebbeck, Timothy R; Domchek, Susan M.

Genet Test ; 12(1): 81-91, 2008 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-18373407

14.

Validity of models for predicting BRCA1 and BRCA2 mutations.

Parmigiani, Giovanni; Chen, Sining; Iversen, Edwin S; Friebel, Tara M; Finkelstein, Dianne M; Anton-Culver, Hoda; Ziogas, Argyrios; Weber, Barbara L; Eisen, Andrea; Malone, Kathleen E; Daling, Janet R; Hsu, Li; Ostrander, Elaine A; Peterson, Leif E; Schildkraut, Joellen M; Isaacs, Claudine; Corio, Camille; Leondaridis, Leoni; Tomlinson, Gail; Amos, Christopher I; Strong, Louise C; Berry, Donald A; Weitzel, Jeffrey N; Sand, Sharon; Dutson, Debra; Kerber, Rich; Peshkin, Beth N; Euhus, David M.

Ann Intern Med ; 147(7): 441-50, 2007 Oct 02.

Artículo en Inglés | MEDLINE | ID: mdl-17909205

15.

Integrative genomic analysis of protein kinase C (PKC) family identifies PKCiota as a biomarker and potential oncogene in ovarian carcinoma.

Zhang, Lin; Huang, Jia; Yang, Nuo; Liang, Shun; Barchetti, Andrea; Giannakakis, Antonis; Cadungog, Mark G; O'Brien-Jenkins, Ann; Massobrio, Marco; Roby, Katherine F; Katsaros, Dionyssios; Gimotty, Phyllis; Butzow, Ralf; Weber, Barbara L; Coukos, George.

Cancer Res ; 66(9): 4627-35, 2006 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-16651413

16.

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations.

Rebbeck, Timothy R; Lynch, Henry T; Neuhausen, Susan L; Narod, Steven A; Van't Veer, Laura; Garber, Judy E; Evans, Gareth; Isaacs, Claudine; Daly, Mary B; Matloff, Ellen; Olopade, Olufunmilayo I; Weber, Barbara L.

N Engl J Med ; 346(21): 1616-22, 2002 May 23.

Artículo en Inglés | MEDLINE | ID: mdl-12023993

17.

Large genomic rearrangement in BRCA1 and BRCA2 and clinical characteristics of men with breast cancer in the United States.

Tchou, Julia; Ward, M Renee; Volpe, Patricia; Palma, Maurizia Dalla; Medina, C Angelina; Sargen, Michael; Sonnad, Seema S; Godwin, Andrew K; Daly, Mary; Winchester, David J; Garber, Judy; Weber, Barbara L; Domchek, Susan; Nathanson, Katherine L.

Clin Breast Cancer ; 7(8): 627-33, 2007 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-17592676

18.

BRAF as a potential therapeutic target in melanoma and other malignancies.

Tuveson, David A; Weber, Barbara L; Herlyn, Meenhard.

Cancer Cell ; 4(2): 95-8, 2003 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-12957284

19.

Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization.

Jönsson, Göran; Naylor, Tara L; Vallon-Christersson, Johan; Staaf, Johan; Huang, Jia; Ward, M Renee; Greshock, Joel D; Luts, Lena; Olsson, Håkan; Rahman, Nazneen; Stratton, Michael; Ringnér, Markus; Borg, Ake; Weber, Barbara L.

Cancer Res ; 65(17): 7612-21, 2005 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-16140926

20.

Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth.

Zhang, Lin; Yang, Nuo; Huang, Jia; Buckanovich, Ronald J; Liang, Shun; Barchetti, Andrea; Vezzani, Cristina; O'Brien-Jenkins, Ann; Wang, Jennifer; Ward, Michelle Renee; Courreges, Maria C; Fracchioli, Stefano; Medina, Angelica; Katsaros, Dionyssios; Weber, Barbara L; Coukos, George.

Cancer Res ; 65(3): 925-32, 2005 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-15705892

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