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1.
Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM).
Br J Cancer
; 125(4): 582-592, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34088988
2.
Inhibition of USP10 induces degradation of oncogenic FLT3.
Nat Chem Biol
; 13(12): 1207-1215, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28967922
3.
Structure-guided development of covalent TAK1 inhibitors.
Bioorg Med Chem
; 25(3): 838-846, 2017 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28011204
4.
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
Bioorg Med Chem
; 25(4): 1320-1328, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28038940
5.
Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia.
Haematologica
; 106(2): 605-609, 2021 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32299905
6.
BRD9 regulates normal human hematopoietic stem cell function and lineage differentiation.
Cell Death Differ
; 2024 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38816579
7.
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.
Leukemia
; 36(1): 210-220, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34326465
8.
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2.
Leukemia
; 36(4): 1048-1057, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35034955
9.
3D tissue engineered plasma cultures support leukemic proliferation and induces drug resistance.
Leuk Lymphoma
; 62(10): 2457-2465, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33993837
10.
Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
Cancers (Basel)
; 13(1)2020 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33374980
11.
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
Sci Rep
; 10(1): 5324, 2020 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32210275
12.
Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia.
J Med Chem
; 62(2): 875-892, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30565931
13.
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.
Cell Chem Biol
; 25(1): 88-99.e6, 2018 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29129717
14.
Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming.
Oncotarget
; 8(40): 67639-67650, 2017 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28978059
15.
Inhibition of SDF-1-induced migration of oncogene-driven myeloid leukemia by the L-RNA aptamer (Spiegelmer), NOX-A12, and potentiation of tyrosine kinase inhibition.
Oncotarget
; 8(66): 109973-109984, 2017 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29299123
16.
Structure-Guided Development of a Potent and Selective Non-covalent Active-Site Inhibitor of USP7.
Cell Chem Biol
; 24(12): 1490-1500.e11, 2017 12 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-29056421
17.
Characterization of midostaurin as a dual inhibitor of FLT3 and SYK and potentiation of FLT3 inhibition against FLT3-ITD-driven leukemia harboring activated SYK kinase.
Oncotarget
; 8(32): 52026-52044, 2017 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28881711
18.
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors.
Eur J Med Chem
; 137: 545-557, 2017 Sep 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28628824
19.
HSP70 and FLT3-ITD: Targeting chaperone system to overcome drug resistance.
Blood Sci
; 3(4): 151-153, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35402847
20.
Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia.
Signal Transduct Target Ther
; 6(1): 334, 2021 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34521806