Detalles de la búsqueda
1.
Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases.
J Autoimmun
; 111: 102436, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32220507
2.
A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts.
Am J Respir Crit Care Med
; 195(10): 1311-1320, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27925796
3.
Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti-IL-17 receptor monoclonal antibody.
J Immunol
; 192(8): 3828-36, 2014 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24646743
4.
Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-γ IgG1 monoclonal antibody, in patients with systemic lupus erythematosus.
Pharm Res
; 32(2): 640-53, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25213774
5.
Maximizing the sensitivity and reliability of peptide identification in large-scale proteomic experiments by harnessing multiple search engines.
Proteomics
; 10(6): 1172-89, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20101609
6.
Evidence for endotoxin contamination in plastic Na+-heparin blood collection tube lots.
Clin Chem
; 56(9): 1483-91, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20663962
7.
ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes.
J Immunol
; 181(2): 1019-24, 2008 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18606653
8.
CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Cell Immunol
; 259(2): 177-84, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19646680
9.
Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 51(6): 1637-48, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18278858
10.
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
J Med Chem
; 51(6): 1681-94, 2008 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-18321037
11.
Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus.
Arthritis Rheumatol
; 69(5): 1028-1034, 2017 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28118537
12.
Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis.
Lupus Sci Med
; 4(1): e000226, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29018537
13.
Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.
J Med Chem
; 49(16): 4981-91, 2006 Aug 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-16884310
14.
Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.
J Med Chem
; 49(19): 5671-86, 2006 Sep 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16970394
15.
Blockade of interferon-γ normalizes interferon-regulated gene expression and serum CXCL10 levels in patients with systemic lupus erythematosus.
Arthritis Rheumatol
; 67(10): 2713-22, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26138472
16.
Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells.
PLoS One
; 4(11): e7525, 2009 Nov 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19888475
17.
Regulation of T cell activation and tolerance by PDL2.
Proc Natl Acad Sci U S A
; 103(31): 11695-700, 2006 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16864790
18.
ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.
J Immunol
; 177(7): 4927-32, 2006 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16982935
19.
CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.
J Immunol
; 176(7): 4419-30, 2006 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16547280
20.
Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis.
J Allergy Clin Immunol
; 112(5): 958-64, 2003 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-14610488