Detalles de la búsqueda
1.
Nonpeptide angiotensin II receptor antagonists. Studies with EXP9270 and DuP 753.
Hypertension
; 15(6 Pt 2): 823-34, 1990 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-2351436
2.
Hypotensive action of DuP 753, an angiotensin II antagonist, in spontaneously hypertensive rats. Nonpeptide angiotensin II receptor antagonists: X.
Hypertension
; 15(5): 459-68, 1990 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-2185150
3.
Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.
Hypertension
; 18(5 Suppl): III136-42, 1991 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-1937677
4.
The design and synthesis of noncovalent factor Xa inhibitors.
Curr Top Med Chem
; 1(2): 137-49, 2001 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-11899249
5.
A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.
J Med Chem
; 36(25): 3985-92, 1993 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-8258820
6.
Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.
J Med Chem
; 38(15): 2938-45, 1995 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-7636854
7.
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.
J Med Chem
; 34(8): 2525-47, 1991 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-1875348
8.
Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists.
J Med Chem
; 40(1): 50-60, 1997 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-9016328
9.
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: synthesis and structure-activity relationship studies of a new series of trisubstituted imidazoles.
J Med Chem
; 37(21): 3511-22, 1994 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-7932580
10.
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.
J Med Chem
; 42(15): 2760-73, 1999 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-10425087
11.
Isoxazolines as potent antagonists of the integrin alpha(v)beta(3).
J Med Chem
; 43(1): 27-40, 2000 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-10633036
12.
Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3).
J Med Chem
; 43(1): 41-58, 2000 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-10633037
13.
Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.
J Med Chem
; 42(15): 2752-9, 1999 Jul 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-10425086
14.
Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors.
J Med Chem
; 43(23): 4398-415, 2000 Nov 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-11087565
15.
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
J Med Chem
; 44(21): 3347-50, 2001 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11585439
16.
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
J Med Chem
; 44(21): 3351-4, 2001 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-11585440
17.
Orally active isoxazoline glycoprotein IIb/IIIa antagonists with extended duration of action.
J Med Chem
; 42(7): 1178-92, 1999 Apr 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-10197962
18.
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.
J Med Chem
; 44(4): 566-78, 2001 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-11170646
19.
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
J Med Chem
; 44(16): 2636-60, 2001 Aug 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11472217
20.
In vivo pharmacology of DuP 753.
Am J Hypertens
; 4(4 Pt 2): 288S-298S, 1991 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-1854454