Detalles de la búsqueda
1.
Identification and characterization of aptameric inhibitors of human neutrophil elastase.
J Biol Chem
; 299(8): 104889, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37286041
2.
First-in-human study of CPL207280, a novel G-protein-coupled receptor 40/free fatty acid receptor 1 agonist, in healthy volunteers after single and multiple administration.
Diabetes Obes Metab
; 26(4): 1376-1385, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38204407
3.
Fibroblast Growth Factor Receptor Inhibitors Decrease Proliferation of Melanoma Cell Lines and Their Activity Is Modulated by Vitamin D.
Int J Mol Sci
; 25(5)2024 Feb 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-38473753
4.
Tuning the Biological Activity of PI3Kδ Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow.
Molecules
; 28(8)2023 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37110764
5.
Esketamine inhaled as dry powder: Pharmacokinetic, pharmacodynamic and safety assessment in a preclinical study.
Pulm Pharmacol Ther
; 73-74: 102127, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35429651
6.
FGFR1-4 RNA-Based Gene Alteration and Expression Analysis in Squamous Non-Small Cell Lung Cancer.
Int J Mol Sci
; 23(18)2022 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36142417
7.
Implementation of QbD Approach to the Development of Chromatographic Methods for the Determination of Complete Impurity Profile of Substance on the Preclinical and Clinical Step of Drug Discovery Studies.
Int J Mol Sci
; 23(18)2022 Sep 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36142622
8.
CPL207280, a Novel G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1-Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals.
Mol Pharmacol
; 100(4): 335-347, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34349026
9.
A novel JAK/ROCK inhibitor, CPL409116, demonstrates potent efficacy in the mouse model of systemic lupus erythematosus.
J Pharmacol Sci
; 145(4): 340-348, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33712286
10.
Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil.
J Enzyme Inhib Med Chem
; 35(1): 1743-1750, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32938236
11.
Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
Gastric Cancer
; 19(1): 53-62, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25407459
12.
Cell-based assay for low- and high-scale screening of the Wnt/ß-catenin signaling modulators.
Anal Biochem
; 475: 56-67, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25659657
13.
Transcriptional expression of selected genes associated with excretion of carboxylic acids from aci mutants of Saccharomyces cerevisiae.
Postepy Hig Med Dosw (Online)
; 67: 352-7, 2013 Apr 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-23667093
14.
Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery.
Biomedicines
; 11(10)2023 Oct 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37893125
15.
Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancer.
Front Oncol
; 13: 1293728, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38282676
16.
[Role of CEACAM in neutrophil activation]. / Rola CEACAM w aktywacji granulocytów obojetnochlonnych.
Postepy Hig Med Dosw (Online)
; 66: 574-82, 2012 Aug 24.
Artículo
en Polaco
| MEDLINE | ID: mdl-22922158
17.
Two-Front War on Cancer-Targeting TAM Receptors in Solid Tumour Therapy.
Cancers (Basel)
; 14(10)2022 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-35626092
18.
The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415).
RSC Adv
; 12(52): 33605-33611, 2022 Nov 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36505705
19.
A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects.
Front Pharmacol
; 13: 999685, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36438799
20.
Design, Synthesis, and Development of Pyrazolo[1,5-a]pyrimidine Derivatives as a Novel Series of Selective PI3Kδ Inhibitors: Part II-Benzimidazole Derivatives.
Pharmaceuticals (Basel)
; 15(8)2022 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-36015075