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1.
CYP1-Activation and Anticancer Properties of Synthetic Methoxylated Resveratrol Analogues.
Molecules
; 29(2)2024 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38257336
2.
The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells.
Bioorg Med Chem Lett
; 29(11): 1403-1406, 2019 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30935796
3.
Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase-2 (SHP2).
J Med Chem
; 67(6): 4655-4675, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38462716
4.
ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK.
Mol Cancer Ther
; 20(10): 1757-1768, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34330842
5.
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 64(16): 12286-12303, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34387469
6.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(7): 4071-4088, 2021 04 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-33761253
7.
Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity.
Mol Cancer Ther
; 6(12 Pt 1): 3147-57, 2007 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18089709
8.
The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells.
Med Chem
; 14(4): 322-332, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29332599
9.
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.
Mol Cancer Ther
; 17(7): 1381-1391, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695633
10.
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).
J Med Chem
; 61(16): 7314-7329, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30091600
11.
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J Med Chem
; 61(11): 4978-4992, 2018 06 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29775310
12.
Cytochrome P450 CYP1 metabolism of hydroxylated flavones and flavonols: Selective bioactivation of luteolin in breast cancer cells.
Food Chem Toxicol
; 110: 383-394, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29097115
13.
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
J Med Chem
; 60(11): 4611-4625, 2017 06 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28492317
14.
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.
J Med Chem
; 58(16): 6574-88, 2015 Aug 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-26218264
15.
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
J Med Chem
; 53(14): 5213-28, 2010 Jul 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-20565112
16.
The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.
Drug Metab Dispos
; 35(7): 1017-22, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17403917
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