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1.
Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics.
Bull Math Biol
; 86(1): 2, 2023 11 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37999811
2.
Protocol-Dependent Differences in IC50 Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding.
Mol Pharmacol
; 95(5): 537-550, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30770456
3.
The Temperature Dependence of Kinetics Associated with Drug Block of hERG Channels Is Compound-Specific and an Important Factor for Proarrhythmic Risk Prediction.
Mol Pharmacol
; 94(1): 760-769, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29728448
4.
Temperature Effects on Kinetics of KV11.1 Drug Block Have Important Consequences for In Silico Proarrhythmic Risk Prediction.
Mol Pharmacol
; 90(1): 1-11, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27190211
5.
Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome.
Biophys Rev
; 14(1): 353-367, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-35103080
6.
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol.
J Pharmacol Toxicol Methods
; 117: 107192, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35750310
7.
Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.
Br J Pharmacol
; 179(11): 2631-2646, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-34837219
8.
A novel family of insect-selective peptide neurotoxins targeting insect large-conductance calcium-activated K+ channels isolated from the venom of the theraphosid spider Eucratoscelus constrictus.
Mol Pharmacol
; 80(1): 1-13, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21447641
9.
Heterozygous KCNH2 variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology.
Biol Methods Protoc
; 6(1): bpab003, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33884304
10.
A nonlinear and time-dependent leak current in the presence of calcium fluoride patch-clamp seal enhancer.
Wellcome Open Res
; 5: 152, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-34805549
11.
A constricted opening in Kir channels does not impede potassium conduction.
Nat Commun
; 11(1): 3024, 2020 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32541684
12.
The Janus-faced atracotoxins are specific blockers of invertebrate K(Ca) channels.
FEBS J
; 275(16): 4045-59, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18625007
13.
Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities.
Front Pharmacol
; 9: 1035, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30333745
14.
Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.
Biomedicines
; 6(3)2018 Aug 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30154370
15.
In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.
Front Physiol
; 8: 934, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29201009
16.
Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors.
Neuropharmacology
; 127: 224-242, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28396143
17.
Measuring kinetics and potency of hERG block for CiPA.
J Pharmacol Toxicol Methods
; 87: 99-107, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28192183
18.
In silico assessment of kinetics and state dependent binding properties of drugs causing acquired LQTS.
Prog Biophys Mol Biol
; 120(1-3): 89-99, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26713558
19.
Direct visualization of disulfide bonds through diselenide proxies using 77Se NMR spectroscopy.
Angew Chem Int Ed Engl
; 48(49): 9312-4, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19890933
20.
Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?
Antioxid Redox Signal
; 19(16): 1976-80, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23646911