Búsqueda | Biblioteca Virtual en Salud

1.

T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.

Hirschhorn, Daniel; Budhu, Sadna; Kraehenbuehl, Lukas; Gigoux, Mathieu; Schröder, David; Chow, Andrew; Ricca, Jacob M; Gasmi, Billel; De Henau, Olivier; Mangarin, Levi Mark B; Li, Yanyun; Hamadene, Linda; Flamar, Anne-Laure; Choi, Hyejin; Cortez, Czrina A; Liu, Cailian; Holland, Aliya; Schad, Sara; Schulze, Isabell; Betof Warner, Allison; Hollmann, Travis J; Arora, Arshi; Panageas, Katherine S; Rizzuto, Gabrielle A; Duhen, Rebekka; Weinberg, Andrew D; Spencer, Christine N; Ng, David; He, Xue-Yan; Albrengues, Jean; Redmond, David; Egeblad, Mikala; Wolchok, Jedd D; Merghoub, Taha.

Cell ; 186(7): 1432-1447.e17, 2023 03 30.

Artículo en Inglés | MEDLINE | ID: mdl-37001503

2.

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

Lu, Sydney X; De Neef, Emma; Thomas, James D; Sabio, Erich; Rousseau, Benoit; Gigoux, Mathieu; Knorr, David A; Greenbaum, Benjamin; Elhanati, Yuval; Hogg, Simon J; Chow, Andrew; Ghosh, Arnab; Xie, Abigail; Zamarin, Dmitriy; Cui, Daniel; Erickson, Caroline; Singer, Michael; Cho, Hana; Wang, Eric; Lu, Bin; Durham, Benjamin H; Shah, Harshal; Chowell, Diego; Gabel, Austin M; Shen, Yudao; Liu, Jing; Jin, Jian; Rhodes, Matthew C; Taylor, Richard E; Molina, Henrik; Wolchok, Jedd D; Merghoub, Taha; Diaz, Luis A; Abdel-Wahab, Omar; Bradley, Robert K.

Cell ; 184(15): 4032-4047.e31, 2021 07 22.

Artículo en Inglés | MEDLINE | ID: mdl-34171309

3.

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.

Benci, Joseph L; Johnson, Lexus R; Choa, Ruth; Xu, Yuanming; Qiu, Jingya; Zhou, Zilu; Xu, Bihui; Ye, Darwin; Nathanson, Katherine L; June, Carl H; Wherry, E John; Zhang, Nancy R; Ishwaran, Hemant; Hellmann, Matthew D; Wolchok, Jedd D; Kambayashi, Taku; Minn, Andy J.

Cell ; 178(4): 933-948.e14, 2019 08 08.

Artículo en Inglés | MEDLINE | ID: mdl-31398344

4.

Putting the Immunologic Brakes on Cancer.

Wolchok, Jedd.

Cell ; 175(6): 1452-1454, 2018 11 29.

Artículo en Inglés | MEDLINE | ID: mdl-30500529

5.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

Shukla, Sachet A; Bachireddy, Pavan; Schilling, Bastian; Galonska, Christina; Zhan, Qian; Bango, Clyde; Langer, Rupert; Lee, Patrick C; Gusenleitner, Daniel; Keskin, Derin B; Babadi, Mehrtash; Mohammad, Arman; Gnirke, Andreas; Clement, Kendell; Cartun, Zachary J; Van Allen, Eliezer M; Miao, Diana; Huang, Ying; Snyder, Alexandra; Merghoub, Taha; Wolchok, Jedd D; Garraway, Levi A; Meissner, Alexander; Weber, Jeffrey S; Hacohen, Nir; Neuberg, Donna; Potts, Patrick R; Murphy, George F; Lian, Christine G; Schadendorf, Dirk; Hodi, F Stephen; Wu, Catherine J.

Cell ; 173(3): 624-633.e8, 2018 04 19.

Artículo en Inglés | MEDLINE | ID: mdl-29656892

6.

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.

Wang, Haiping; Franco, Fabien; Tsui, Yao-Chen; Xie, Xin; Trefny, Marcel P; Zappasodi, Roberta; Mohmood, Syed Raza; Fernández-García, Juan; Tsai, Chin-Hsien; Schulze, Isabell; Picard, Florence; Meylan, Etienne; Silverstein, Roy; Goldberg, Ira; Fendt, Sarah-Maria; Wolchok, Jedd D; Merghoub, Taha; Jandus, Camilla; Zippelius, Alfred; Ho, Ping-Chih.

Nat Immunol ; 21(3): 298-308, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-32066953

7.

The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer.

Chow, Andrew; Uddin, Fathema Z; Liu, Michael; Dobrin, Anton; Nabet, Barzin Y; Mangarin, Levi; Lavin, Yonit; Rizvi, Hira; Tischfield, Sam E; Quintanal-Villalonga, Alvaro; Chan, Joseph M; Shah, Nisargbhai; Allaj, Viola; Manoj, Parvathy; Mattar, Marissa; Meneses, Maximiliano; Landau, Rebecca; Ward, Mariana; Kulick, Amanda; Kwong, Charlene; Wierzbicki, Matthew; Yavner, Jessica; Egger, Jacklynn; Chavan, Shweta S; Farillas, Abigail; Holland, Aliya; Sridhar, Harsha; Ciampricotti, Metamia; Hirschhorn, Daniel; Guan, Xiangnan; Richards, Allison L; Heller, Glenn; Mansilla-Soto, Jorge; Sadelain, Michel; Klebanoff, Christopher A; Hellmann, Matthew D; Sen, Triparna; de Stanchina, Elisa; Wolchok, Jedd D; Merghoub, Taha; Rudin, Charles M.

Immunity ; 56(1): 93-106.e6, 2023 01 10.

Artículo en Inglés | MEDLINE | ID: mdl-36574773

8.

Curbing Tregs' (Lack of) Enthusiasm.

Merghoub, Taha; Wolchok, Jedd D.

Cell ; 169(6): 981-982, 2017 06 01.

Artículo en Inglés | MEDLINE | ID: mdl-28575677

9.

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Jiménez-Sánchez, Alejandro; Memon, Danish; Pourpe, Stephane; Veeraraghavan, Harini; Li, Yanyun; Vargas, Hebert Alberto; Gill, Michael B; Park, Kay J; Zivanovic, Oliver; Konner, Jason; Ricca, Jacob; Zamarin, Dmitriy; Walther, Tyler; Aghajanian, Carol; Wolchok, Jedd D; Sala, Evis; Merghoub, Taha; Snyder, Alexandra; Miller, Martin L.

Cell ; 170(5): 927-938.e20, 2017 Aug 24.

Artículo en Inglés | MEDLINE | ID: mdl-28841418

10.

Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance.

Verma, Vivek; Shrimali, Rajeev K; Ahmad, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandre, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L; Flaherty, Keith T; Wargo, Jennifer A; Boland, Genevieve M; Sullivan, Ryan J; Getz, Gad; Hammond, Scott A; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N.

Nat Immunol ; 20(11): 1555, 2019 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-31551574

11.

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance.

Verma, Vivek; Shrimali, Rajeev K; Ahmad, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandre, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L; Flaherty, Keith T; Wargo, Jennifer A; Boland, Genevieve M; Sullivan, Ryan J; Getz, Gad; Hammond, Scott A; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N.

Nat Immunol ; 20(9): 1231-1243, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31358999

12.

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

Xu, Shihao; Chaudhary, Omkar; Rodríguez-Morales, Patricia; Sun, Xiaoli; Chen, Dan; Zappasodi, Roberta; Xu, Ziyan; Pinto, Antonio F M; Williams, April; Schulze, Isabell; Farsakoglu, Yagmur; Varanasi, Siva Karthik; Low, Jun Siong; Tang, Wenxi; Wang, Haiping; McDonald, Bryan; Tripple, Victoria; Downes, Michael; Evans, Ronald M; Abumrad, Nada A; Merghoub, Taha; Wolchok, Jedd D; Shokhirev, Maxim N; Ho, Ping-Chih; Witztum, Joseph L; Emu, Brinda; Cui, Guoliang; Kaech, Susan M.

Immunity ; 54(7): 1561-1577.e7, 2021 07 13.

Artículo en Inglés | MEDLINE | ID: mdl-34102100

13.

PD-1 Blockers.

Wolchok, Jedd D.

Cell ; 162(5): 937, 2015 Aug 27.

Artículo en Inglés | MEDLINE | ID: mdl-26317459

14.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Chiappinelli, Katherine B; Strissel, Pamela L; Desrichard, Alexis; Li, Huili; Henke, Christine; Akman, Benjamin; Hein, Alexander; Rote, Neal S; Cope, Leslie M; Snyder, Alexandra; Makarov, Vladimir; Budhu, Sadna; Buhu, Sadna; Slamon, Dennis J; Wolchok, Jedd D; Pardoll, Drew M; Beckmann, Matthias W; Zahnow, Cynthia A; Merghoub, Taha; Mergoub, Taha; Chan, Timothy A; Baylin, Stephen B; Strick, Reiner.

Cell ; 162(5): 974-86, 2015 Aug 27.

Artículo en Inglés | MEDLINE | ID: mdl-26317466

15.

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.

Rojas, Luis A; Sethna, Zachary; Soares, Kevin C; Olcese, Cristina; Pang, Nan; Patterson, Erin; Lihm, Jayon; Ceglia, Nicholas; Guasp, Pablo; Chu, Alexander; Yu, Rebecca; Chandra, Adrienne Kaya; Waters, Theresa; Ruan, Jennifer; Amisaki, Masataka; Zebboudj, Abderezak; Odgerel, Zagaa; Payne, George; Derhovanessian, Evelyna; Müller, Felicitas; Rhee, Ina; Yadav, Mahesh; Dobrin, Anton; Sadelain, Michel; Luksza, Marta; Cohen, Noah; Tang, Laura; Basturk, Olca; Gönen, Mithat; Katz, Seth; Do, Richard Kinh; Epstein, Andrew S; Momtaz, Parisa; Park, Wungki; Sugarman, Ryan; Varghese, Anna M; Won, Elizabeth; Desai, Avni; Wei, Alice C; D'Angelica, Michael I; Kingham, T Peter; Mellman, Ira; Merghoub, Taha; Wolchok, Jedd D; Sahin, Ugur; Türeci, Özlem; Greenbaum, Benjamin D; Jarnagin, William R; Drebin, Jeffrey; O'Reilly, Eileen M.

Nature ; 618(7963): 144-150, 2023 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-37165196

16.

Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Hoyos, David; Zappasodi, Roberta; Schulze, Isabell; Sethna, Zachary; de Andrade, Kelvin César; Bajorin, Dean F; Bandlamudi, Chaitanya; Callahan, Margaret K; Funt, Samuel A; Hadrup, Sine R; Holm, Jeppe S; Rosenberg, Jonathan E; Shah, Sohrab P; Vázquez-García, Ignacio; Weigelt, Britta; Wu, Michelle; Zamarin, Dmitriy; Campitelli, Laura F; Osborne, Edward J; Klinger, Mark; Robins, Harlan S; Khincha, Payal P; Savage, Sharon A; Balachandran, Vinod P; Wolchok, Jedd D; Hellmann, Matthew D; Merghoub, Taha; Levine, Arnold J; Luksza, Marta; Greenbaum, Benjamin D.

Nature ; 606(7912): 172-179, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-35545680

17.

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.

Luksza, Marta; Sethna, Zachary M; Rojas, Luis A; Lihm, Jayon; Bravi, Barbara; Elhanati, Yuval; Soares, Kevin; Amisaki, Masataka; Dobrin, Anton; Hoyos, David; Guasp, Pablo; Zebboudj, Abderezak; Yu, Rebecca; Chandra, Adrienne Kaya; Waters, Theresa; Odgerel, Zagaa; Leung, Joanne; Kappagantula, Rajya; Makohon-Moore, Alvin; Johns, Amber; Gill, Anthony; Gigoux, Mathieu; Wolchok, Jedd; Merghoub, Taha; Sadelain, Michel; Patterson, Erin; Monasson, Remi; Mora, Thierry; Walczak, Aleksandra M; Cocco, Simona; Iacobuzio-Donahue, Christine; Greenbaum, Benjamin D; Balachandran, Vinod P.

Nature ; 606(7913): 389-395, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-35589842

18.

Anatomic position determines oncogenic specificity in melanoma.

Weiss, Joshua M; Hunter, Miranda V; Cruz, Nelly M; Baggiolini, Arianna; Tagore, Mohita; Ma, Yilun; Misale, Sandra; Marasco, Michelangelo; Simon-Vermot, Theresa; Campbell, Nathaniel R; Newell, Felicity; Wilmott, James S; Johansson, Peter A; Thompson, John F; Long, Georgina V; Pearson, John V; Mann, Graham J; Scolyer, Richard A; Waddell, Nicola; Montal, Emily D; Huang, Ting-Hsiang; Jonsson, Philip; Donoghue, Mark T A; Harris, Christopher C; Taylor, Barry S; Xu, Tianhao; Chaligné, Ronan; Shliaha, Pavel V; Hendrickson, Ronald; Jungbluth, Achim A; Lezcano, Cecilia; Koche, Richard; Studer, Lorenz; Ariyan, Charlotte E; Solit, David B; Wolchok, Jedd D; Merghoub, Taha; Rosen, Neal; Hayward, Nicholas K; White, Richard M.

Nature ; 604(7905): 354-361, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35355015

19.

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c⁺CD103⁺ Monocytic Antigen-Presenting Cells in Tumors.

Sharma, Madhav D; Rodriguez, Paulo C; Koehn, Brent H; Baban, Babak; Cui, Yan; Guo, Gang; Shimoda, Michiko; Pacholczyk, Rafal; Shi, Huidong; Lee, Eun-Joon; Xu, Hongyan; Johnson, Theodore S; He, Yukai; Mergoub, Taha; Venable, Christopher; Bronte, Vincenzo; Wolchok, Jedd D; Blazar, Bruce R; Munn, David H.

Immunity ; 48(1): 91-106.e6, 2018 01 16.

Artículo en Inglés | MEDLINE | ID: mdl-29343444

20.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Chiappinelli, Katherine B; Strissel, Pamela L; Desrichard, Alexis; Li, Huili; Henke, Christine; Akman, Benjamin; Hein, Alexander; Rote, Neal S; Cope, Leslie M; Snyder, Alexandra; Makarov, Vladimir; Budhu, Sadna; Slamon, Dennis J; Wolchok, Jedd D; Pardoll, Drew M; Beckmann, Matthias W; Zahnow, Cynthia A; Merghoub, Taha; Chan, Timothy A; Baylin, Stephen B; Strick, Reiner.

Cell ; 169(2): 361, 2017 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-28388418

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.

Putting the Immunologic Brakes on Cancer.

Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.

The ectonucleotidase CD39 identifies tumor-reactive CD8⁺ T cells predictive of immune checkpoint blockade efficacy in human lung cancer.

Curbing Tregs' (Lack of) Enthusiasm.

Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.

Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance.

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1⁺CD38^hi cells and anti-PD-1 resistance.

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors.

PD-1 Blockers.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer.

Fundamental immune-oncogenicity trade-offs define driver mutation fitness.

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.

Anatomic position determines oncogenic specificity in melanoma.

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c⁺CD103⁺ Monocytic Antigen-Presenting Cells in Tumors.

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.