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1.
Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.
Drug Metab Dispos
; 44(8): 1262-9, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27079250
2.
Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.
Drug Metab Dispos
; 44(2): 209-19, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26608081
3.
Toxicities associated with 1-month treatment with propylthiouracil (PTU) and methimazole (MMI) in male rats.
Toxicol Pathol
; 42(6): 970-83, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24067673
4.
A "middle-out" approach to human pharmacokinetic predictions for OATP substrates using physiologically-based pharmacokinetic modeling.
J Pharmacokinet Pharmacodyn
; 41(3): 197-209, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24718648
5.
Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement.
Drug Metab Dispos
; 40(6): 1067-75, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22393119
6.
A novel relay method for determining low-clearance values.
Drug Metab Dispos
; 40(9): 1860-5, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22645091
7.
Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Chem Res Toxicol
; 24(12): 2207-16, 2011 Dec 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-21939274
8.
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.
Bioorg Med Chem Lett
; 21(14): 4150-4, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21684740
9.
Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.
PLoS One
; 13(11): e0206279, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30427871
10.
Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(16): 7273-7288, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30036059
11.
Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
J Med Chem
; 59(17): 8068-81, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27490827
12.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Sci Rep
; 5: 17391, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26620127
13.
Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
J Med Chem
; 58(21): 8513-28, 2015 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-26509551
14.
Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.
ACS Med Chem Lett
; 4(1): 63-8, 2013 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900564
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