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1.
Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells.
Diabetologia
; 63(12): 2628-2640, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32960311
2.
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.
Diabetologia
; 61(3): 641-657, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29185012
3.
Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell Function.
J Biol Chem
; 291(12): 6146-57, 2016 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-26792861
4.
Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.
Hum Mol Genet
; 24(7): 1945-55, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25489054
5.
Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high-phosphate-induced mitochondrial oxidative stress and defective insulin secretion.
FASEB J
; 30(12): 3979-3988, 2016 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-27565711
6.
Physiology: Microbial signals to the brain control weight.
Nature
; 534(7606): 185-7, 2016 06 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27279209
7.
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.
PLoS Genet
; 10(3): e1004160, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24603685
8.
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.
Proc Natl Acad Sci U S A
; 111(38): 13924-9, 2014 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-25201977
9.
CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Diabetologia
; 59(9): 1928-37, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27338624
10.
Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.
Diabetologia
; 59(8): 1702-13, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27155871
11.
Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.
J Biol Chem
; 290(7): 4086-96, 2015 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25548283
12.
Inhibition of the malate-aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion.
Biochem J
; 468(1): 49-63, 2015 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25731850
13.
Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.
Am J Physiol Endocrinol Metab
; 308(11): E933-41, 2015 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25852001
14.
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects ß-cells against stress-induced apoptosis.
Hum Mol Genet
; 27(2): 406, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29186426
15.
Modulation of neuronal pentraxin 1 expression in rat pancreatic ß-cells submitted to chronic glucotoxic stress.
Mol Cell Proteomics
; 11(8): 244-54, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22427704
16.
Time-resolved metabolomics analysis of ß-cells implicates the pentose phosphate pathway in the control of insulin release.
Biochem J
; 450(3): 595-605, 2013 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23282133
17.
Regulation of autophagy by perilysosomal calcium: a new player in ß-cell lipotoxicity.
Exp Mol Med
; 56(2): 273-288, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38297165
18.
Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal ß-cells.
Biochim Biophys Acta
; 1823(10): 1815-24, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22809973
19.
The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {beta}-cells against stress-induced apoptosis.
Hum Mol Genet
; 20(14): 2823-33, 2011 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21536586
20.
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.
EMBO J
; 28(4): 417-28, 2009 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-19165153