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1.
Population pharmacokinetics of intravenous and oral panobinostat in patients with hematologic and solid tumors.
Eur J Clin Pharmacol
; 71(6): 663-672, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25939707
2.
A phase I dose-escalation study of intravenous panobinostat in patients with lymphoma and solid tumors.
Invest New Drugs
; 31(4): 974-85, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23377661
3.
A randomized dose-escalation study to assess the safety, tolerability, and pharmacokinetics of ruxolitinib (INC424) in healthy Japanese volunteers.
Int J Hematol
; 97(3): 351-9, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23381973
4.
A clinical investigation of inhibitory effect of panobinostat on CYP2D6 substrate in patients with advanced cancer.
Cancer Chemother Pharmacol
; 72(4): 747-55, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24013574
5.
Characterizing the disposition, metabolism, and excretion of an orally active pan-deacetylase inhibitor, panobinostat, via trace radiolabeled 14C material in advanced cancer patients.
Cancer Chemother Pharmacol
; 70(4): 513-22, 2012 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-22864948
6.
The effect of food on the bioavailability of panobinostat, an orally active pan-histone deacetylase inhibitor, in patients with advanced cancer.
Cancer Chemother Pharmacol
; 69(2): 555-62, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22057852
7.
Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.
Cancer Chemother Pharmacol
; 68(3): 805-13, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21706316
8.
A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.
Cancer Chemother Pharmacol
; 66(1): 181-9, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20217089
9.
Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro.
Cancer Chemother Pharmacol
; 64(5): 867-75, 2009 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19198839
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