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1.
Characterization of the Onset, Progression, and Reversibility of Morphological Changes in Mouse Lung after Pharmacological Inhibition of Leucine-Rich Kinase 2 Kinase Activity.
J Pharmacol Exp Ther
; 377(1): 11-19, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33509901
2.
Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation.
J Pharmacol Exp Ther
; 369(2): 223-233, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30804001
3.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37861679
4.
Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease.
Pharmaceutics
; 14(11)2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36365202
5.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34967623
6.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36475697
7.
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases.
ACS Med Chem Lett
; 11(2): 114-119, 2020 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32071676
8.
Transferring Luminex® cytokine assays to a wall-less plate technology: Validation and comparison study with plasma and cell culture supernatants.
J Immunol Methods
; 440: 74-82, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27840065
9.
Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions.
J Aerosol Med Pulm Drug Deliv
; 29(4): 362-77, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26859446
10.
Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation.
Eur J Pharmacol
; 743: 106-16, 2014 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25261040
11.
Mineralocorticoid receptor antagonists attenuate pulmonary inflammation and bleomycin-evoked fibrosis in rodent models.
Eur J Pharmacol
; 718(1-3): 290-8, 2013 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24012780
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