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1.
Molecular Distribution, 13C-Isotope, and Enantiomeric Compositions of Carbonaceous Chondrite Monocarboxylic Acids.
Meteorit Planet Sci
; 54(2): 415-430, 2019 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-32499671
2.
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Br J Cancer
; 116(9): 1166-1176, 2017 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28334731
3.
Regioselective and enantiospecific synthesis of the HSP co-inducer arimoclomol from chiral glycidyl derivatives.
Org Biomol Chem
; 15(46): 9794-9799, 2017 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-29159344
4.
Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido[3,4-d]pyrimidines.
Org Biomol Chem
; 13(3): 893-904, 2015 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-25407826
5.
Synthesis of mucin-type O-glycan probes as aminopropyl glycosides.
Beilstein J Org Chem
; 9: 1867-72, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24062854
6.
Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J Med Chem
; 65(10): 7212-7230, 2022 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35536179
7.
Structural Analysis and Development of Notum Fragment Screening Hits.
ACS Chem Neurosci
; 13(13): 2060-2077, 2022 07 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35731924
8.
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.
Sci Rep
; 12(1): 18633, 2022 11 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-36329085
9.
The Avon Longitudinal Study of Parents and Children - A resource for COVID-19 research: Antibody testing results, April - June 2021.
Wellcome Open Res
; 6: 283, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-35028425
10.
Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.
J Med Chem
; 64(8): 4289-4311, 2021 04 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33783220
11.
Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.
Bioorg Med Chem Lett
; 20(3): 1219-24, 2010 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20031406
12.
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
J Med Chem
; 63(21): 12942-12956, 2020 11 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33124429
13.
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.
J Med Chem
; 63(17): 9464-9483, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787107
14.
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.
J Med Chem
; 63(8): 4047-4068, 2020 04 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-32275432
15.
The future of cattle veterinary practice: insights from a qualitative study.
Vet Rec
; 185(7): 205, 2019 08 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-31320547
16.
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.
Mol Cancer Ther
; 18(10): 1696-1707, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31575759
17.
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N2-(2-Ethoxy-4-(4-methyl-4 H-1,2,4-triazol-3-yl)phenyl)-6-methyl- N8-neopentylpyrido[3,4- d]pyrimidine-2,8-diamine (BOS172722).
J Med Chem
; 61(18): 8226-8240, 2018 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30199249
18.
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
J Med Chem
; 59(8): 3671-88, 2016 04 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055065
19.
Discovery of novel small-molecule inhibitors of BRD4 using structure-based virtual screening.
J Med Chem
; 56(20): 8073-88, 2013 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24090311
20.
Reactivity of cyclic sulfamidates towards phosphonate-stabilised enolates: synthesis and applications of alpha-phosphono lactams.
Org Biomol Chem
; 5(16): 2636-44, 2007 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-18019539
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