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1.
A ligand-specific kinetic switch regulates glucocorticoid receptor trafficking and function.
J Cell Sci
; 126(Pt 14): 3159-69, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23687373
2.
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J Med Chem
; 65(1): 633-664, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34928601
3.
Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
Bioorg Med Chem Lett
; 21(10): 3037-40, 2011 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21482467
4.
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
J Med Chem
; 64(15): 10711-10741, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34260229
5.
Identification of a Series of N-Methylpyridine-2-carboxamides as Potent and Selective Inhibitors of the Second Bromodomain (BD2) of the Bromo and Extra Terminal Domain (BET) Proteins.
J Med Chem
; 64(15): 10742-10771, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34232650
6.
Template-Hopping Approach Leads to Potent, Selective, and Highly Soluble Bromo and Extraterminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(6): 3249-3281, 2021 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-33662213
7.
Fragment-based Scaffold Hopping: Identification of Potent, Selective, and Highly Soluble Bromo and Extra Terminal Domain (BET) Second Bromodomain (BD2) Inhibitors.
J Med Chem
; 64(15): 10772-10805, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34255512
8.
Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins.
J Med Chem
; 63(17): 9070-9092, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32691591
9.
GSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family.
ACS Med Chem Lett
; 11(8): 1581-1587, 2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32832027
10.
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
J Med Chem
; 63(17): 9020-9044, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32787145
11.
The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.
J Med Chem
; 63(17): 9093-9126, 2020 09 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32702236
12.
Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 19(1): 158-62, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19019676
13.
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
J Med Chem
; 51(9): 2845-52, 2008 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-18396855
14.
A Perspective on Water Site Prediction Methods for Structure Based Drug Design.
Curr Top Med Chem
; 17(23): 2599-2616, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28460610
15.
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.
J Med Chem
; 49(7): 2210-21, 2006 Apr 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16570917
16.
A critical assessment of docking programs and scoring functions.
J Med Chem
; 49(20): 5912-31, 2006 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-17004707
17.
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.
J Med Chem
; 47(18): 4494-506, 2004 Aug 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-15317461
18.
Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.
J Med Chem
; 46(21): 4428-49, 2003 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-14521407
19.
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.
J Med Chem
; 45(1): 1-18, 2002 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-11754575
20.
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
ACS Med Chem Lett
; 4(10): 948-52, 2013 Oct 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900590