Búsqueda | Biblioteca Virtual en Salud

1.

Stoichiometry of the eIF2B complex is maintained by mutual stabilization of subunits.

Wortham, Noel C; Stewart, Joanna D; Harris, Sean; Coldwell, Mark J; Proud, Christopher G.

Biochem J ; 473(5): 571-80, 2016 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-26614765

2.

eIF2B: recent structural and functional insights into a key regulator of translation.

Wortham, Noel C; Proud, Christopher G.

Biochem Soc Trans ; 43(6): 1234-40, 2015 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-26614666

3.

Biochemical effects of mutations in the gene encoding the alpha subunit of eukaryotic initiation factor (eIF) 2B associated with Vanishing White Matter disease.

Wortham, Noel C; Proud, Christopher G.

BMC Med Genet ; 16: 64, 2015 Aug 19.

Artículo en Inglés | MEDLINE | ID: mdl-26285592

4.

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation.

Wortham, Noel C; Martinez, Magdalena; Gordiyenko, Yuliya; Robinson, Carol V; Proud, Christopher G.

FASEB J ; 28(5): 2225-37, 2014 May.

Artículo en Inglés | MEDLINE | ID: mdl-24532666

5.

Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complex.

Wang, Xuemin; Wortham, Noel C; Liu, Rui; Proud, Christopher G.

J Biol Chem ; 287(11): 8263-74, 2012 Mar 09.

Artículo en Inglés | MEDLINE | ID: mdl-22238342

6.

Severity of vanishing white matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexes.

Liu, Rui; van der Lei, Hannemieke D W; Wang, Xuemin; Wortham, Noel C; Tang, Hua; van Berkel, Carola G M; Mufunde, Tsitsi Arikana; Huang, Weida; van der Knaap, Marjo S; Scheper, Gert C; Proud, Christopher G.

Hum Mutat ; 32(9): 1036-45, 2011 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-21560189

7.

CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.

Kemp, Zoe; Rowan, Andrew; Chambers, William; Wortham, Noel; Halford, Sarah; Sieber, Oliver; Mortensen, Neil; von Herbay, Axel; Gunther, Thomas; Ilyas, Mohammad; Tomlinson, Ian.

Cancer Res ; 65(24): 11361-6, 2005 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-16357143

8.

7q deletion mapping and expression profiling in uterine fibroids.

Vanharanta, Sakari; Wortham, Noel C; Laiho, Päivi; Sjöberg, Jari; Aittomäki, Kristiina; Arola, Johanna; Tomlinson, Ian P; Karhu, Auli; Arango, Diego; Aaltonen, Lauri A.

Oncogene ; 24(43): 6545-54, 2005 Sep 29.

Artículo en Inglés | MEDLINE | ID: mdl-15940248

9.

Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations.

Carvajal-Carmona, Luis G; Alam, N Afrina; Pollard, Patrick J; Jones, Angela M; Barclay, Ella; Wortham, Noel; Pignatelli, Massimo; Freeman, Alex; Pomplun, Sabine; Ellis, Ian; Poulsom, Richard; El-Bahrawy, Mona A; Berney, Daniel M; Tomlinson, Ian P M.

J Clin Endocrinol Metab ; 91(8): 3071-5, 2006 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-16757530

10.

Adult-onset leukoencephalopathies with vanishing white matter with novel missense mutations in EIF2B2, EIF2B3, and EIF2B5.

Matsukawa, Takashi; Wang, Xuemin; Liu, Rui; Wortham, Noel C; Onuki, Yuko; Kubota, Akatsuki; Hida, Ayumi; Kowa, Hisatomo; Fukuda, Yoko; Ishiura, Hiroyuki; Mitsui, Jun; Takahashi, Yuji; Aoki, Shigeki; Takizawa, Shunya; Shimizu, Jun; Goto, Jun; Proud, Christopher G; Tsuji, Shoji.

Neurogenetics ; 12(3): 259-61, 2011 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-21484434

11.

Dercum's disease.

Wortham, Noel C; Tomlinson, Ian Pm.

Skinmed ; 4(3): 157-62; quiz 163-4, 2005.

Artículo en Inglés | MEDLINE | ID: mdl-15891252

12.

Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region.

Vanharanta, Sakari; Wortham, Noel C; Langford, Cordelia; El-Bahrawy, Mona; van der Spuy, Zephne; Sjöberg, Jari; Lehtonen, Rainer; Karhu, Auli; Tomlinson, Ian P M; Aaltonen, Lauri A.

Genes Chromosomes Cancer ; 46(5): 451-8, 2007 May.

Artículo en Inglés | MEDLINE | ID: mdl-17285575

13.

Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma.

Wortham, Noel C; Alam, N Afrina; Barclay, Ella; Pollard, Patrick J; Wagner, Bart E; Manek, Sanjiv; Elia, George; Tomlinson, Ian P M.

Fertil Steril ; 86(4): 961-71, 2006 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-16962107

14.

Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome.

Pollard, Patrick; Wortham, Noel; Barclay, Ella; Alam, Afrina; Elia, George; Manek, Sanjiv; Poulsom, Richard; Tomlinson, Ian.

J Pathol ; 205(1): 41-9, 2005 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-15586379

15.

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

Pollard, Patrick J; Wortham, Noel C; Tomlinson, Ian P M.

Ann Med ; 35(8): 632-9, 2003.

Artículo en Inglés | MEDLINE | ID: mdl-14708972

16.

Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia.

Murdoch, Jennifer N; Doudney, Kit; Gerrelli, Dianne; Wortham, Noel; Paternotte, Caroline; Stanier, Philip; Copp, Andrew J.

Mol Cell Neurosci ; 22(1): 62-74, 2003 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-12595239

17.

Single base mutation in the fumarate hydratase gene leading to segmental cutaneous leiomyomatosis.

Huter, Eva; Wortham, Noel C; Hartschuh, Wolfgang; Enk, Alexander; Jappe, Uta.

Acta Derm Venereol ; 88(1): 63-5, 2008.

Artículo en Inglés | MEDLINE | ID: mdl-18176756

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