Detalles de la búsqueda
1.
Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies.
Bioorg Chem
; 134: 106465, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36933339
2.
Discovery of potent and selective Cdc25 phosphatase inhibitors via rapid assembly and in situ screening of Quinonoid-focused libraries.
Bioorg Chem
; 115: 105254, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34426152
3.
Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.
Org Biomol Chem
; 17(12): 3202-3217, 2019 03 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30839042
4.
Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".
Org Biomol Chem
; 16(6): 1014-1028, 2018 02 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29349445
5.
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP.
Eur J Med Chem
; 193: 112237, 2020 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32200201
6.
Recent applications of click chemistry in drug discovery.
Expert Opin Drug Discov
; 14(8): 779-789, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31094231
7.
Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors.
Drug Discov Today
; 24(2): 629-635, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30503804
8.
Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries.
Eur J Med Chem
; 183: 111696, 2019 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31541869
9.
Overview of Recent Strategic Advances in Medicinal Chemistry.
J Med Chem
; 62(21): 9375-9414, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31050421
10.
Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.
Chem Biol Drug Des
; 93(4): 430-437, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30381875
11.
Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors.
RSC Adv
; 9(50): 28961-28986, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32089839
12.
Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.
J Med Chem
; 62(3): 1484-1501, 2019 02 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30624934
13.
Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors.
Medchemcomm
; 9(1): 149-159, 2018 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30108908
14.
Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014-2017).
Expert Opin Ther Pat
; 28(4): 299-316, 2018 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-29411697
15.
Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
Eur J Med Chem
; 158: 478-492, 2018 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30243152
16.
Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.
Chem Biol Drug Des
; 92(6): 2009-2021, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30079476
17.
Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.
ACS Med Chem Lett
; 9(4): 334-338, 2018 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29670696
18.
Further Exploring Solvent-Exposed Tolerant Regions of Allosteric Binding Pocket for Novel HIV-1 NNRTIs Discovery.
ACS Med Chem Lett
; 9(4): 370-375, 2018 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29670703
19.
Novel fused pyrimidine and isoquinoline derivatives as potent HIV-1 NNRTIs: a patent evaluation of WO2016105532A1, WO2016105534A1 and WO2016105564A1.
Expert Opin Ther Pat
; 27(4): 383-391, 2017 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-28276283
20.
Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.
ACS Med Chem Lett
; 8(11): 1188-1193, 2017 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29152052