Detalles de la búsqueda
1.
Discovery and directed evolution of C-C bond formation enzymes for the biosynthesis of ß-hydroxy-α-amino acids and derivatives.
Crit Rev Biotechnol
; : 1-20, 2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38566472
2.
Semirational Engineering of a Thermostable Carbonyl Reductase for the Precision Synthesis of (2R,3R)-2-Methyl-2-benzyl-3-hydroxycyclopentanone and Its Analogues.
J Org Chem
; 88(16): 11905-11912, 2023 08 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37526991
3.
Engineering a Carbonyl Reductase for Scalable Preparation of (S)-3-Cyclopentyl-3-hydroxypropanenitrile, the Key Building Block of Ruxolitinib.
Chembiochem
; 23(5): e202100589, 2022 03 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-34951083
4.
Asymmetric Synthesis of N-Substituted 1,2-Amino Alcohols from Simple Aldehydes and Amines by One-Pot Sequential Enzymatic Hydroxymethylation and Asymmetric Reductive Amination.
Angew Chem Int Ed Engl
; 61(17): e202116344, 2022 04 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35166000
5.
Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of ß-Amino Acids.
Angew Chem Int Ed Engl
; 60(18): 10203-10210, 2021 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33624917
6.
Inverting the Enantiopreference of Nitrilase-Catalyzed Desymmetric Hydrolysis of Prochiral Dinitriles by Reshaping the Binding Pocket with a Mirror-Image Strategy.
Angew Chem Int Ed Engl
; 60(7): 3679-3684, 2021 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33141478
7.
2,3-Dihydroxybenzoic Acid Decarboxylase from Fusarium oxysporum: Crystal Structures and Substrate Recognition Mechanism.
Chembiochem
; 21(20): 2950-2956, 2020 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32421914
8.
Highly Diastereoselective Synthesis of 2,2-Disubstituted Cyclopentane-1,3-diols via Stepwise Ketone Reduction Enabling Concise Chirality Construction.
J Org Chem
; 85(15): 9599-9606, 2020 08 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32668161
9.
Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols.
Biol Chem
; 400(3): 313-321, 2019 02 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-30269104
10.
Distinct Regioselectivity of Fungal P450 Enzymes for Steroidal Hydroxylation.
Appl Environ Microbiol
; 85(18)2019 09 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31324634
11.
A Fungal P450 Enzyme from Thanatephorus cucumeris with Steroid Hydroxylation Capabilities.
Appl Environ Microbiol
; 84(13)2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29728383
12.
Characterization of new recombinant 3-ketosteroid-Δ1-dehydrogenases for the biotransformation of steroids.
Appl Microbiol Biotechnol
; 101(15): 6049-6060, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28634849
13.
Heterologous expression of a GH3 ß-glucosidase from Neurospora crassa in Pichia pastoris with high purity and its application in the hydrolysis of soybean isoflavone glycosides.
Protein Expr Purif
; 119: 75-84, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26596358
14.
Structural analysis reveals the substrate-binding mechanism for the expanded substrate specificity of mutant meso-diaminopimelate dehydrogenase.
Chembiochem
; 16(6): 924-9, 2015 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25754803
15.
Characterization of (R)-selective amine transaminases identified by in silico motif sequence blast.
Appl Microbiol Biotechnol
; 99(6): 2613-21, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25267157
16.
Synthesis of α,ß-unsaturated esters via a chemo-enzymatic chain elongation approach by combining carboxylic acid reduction and Wittig reaction.
Beilstein J Org Chem
; 11: 2245-51, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26664647
17.
Structural and mutational studies on the unusual substrate specificity of meso-diaminopimelate dehydrogenase from Symbiobacterium thermophilum.
Chembiochem
; 15(2): 217-22, 2014 Jan 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24339368
18.
Substrate profiling of cyclohexylamine oxidase and its mutants reveals new biocatalytic potential in deracemization of racemic amines.
Appl Microbiol Biotechnol
; 98(4): 1681-9, 2014 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23793344
19.
Engineering a hydroxysteroid dehydrogenase to improve its soluble expression for the asymmetric reduction of cortisone to 11ß-hydrocortisone.
Appl Microbiol Biotechnol
; 98(21): 8879-86, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25081557
20.
Identification and structure-based engineering of a dipeptidase CpPepD from Clostridium perfringens for the synthesis of l-carnosine.
J Biotechnol
; 389: 86-93, 2024 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38718874