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1.
Transient Hypoxemia Disrupts Anatomical and Functional Maturation of Preterm Fetal Ovine CA1 Pyramidal Neurons.
J Neurosci
; 39(40): 7853-7871, 2019 10 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-31455661
2.
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Toxicol Appl Pharmacol
; 394: 114961, 2020 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32209365
3.
Functional changes in hippocampal synaptic signaling in offspring survivors of a mouse model of intrauterine inflammation.
J Neuroinflammation
; 14(1): 180, 2017 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-28874190
4.
Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961].
Toxicol Appl Pharmacol
; 395: 114983, 2020 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32247767
5.
Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses.
J Neurosci
; 33(41): 16158-69, 2013 Oct 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-24107948
6.
ICH S7B In Vitro Assays Do Not Address Mechanisms of QTC Prolongation for Peptides and Proteins - Data in Support of Not Needing Dedicated QTC Studies.
Clin Pharmacol Ther
; 114(6): 1332-1341, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37702218
7.
Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons.
J Neurosci
; 31(7): 2638-48, 2011 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-21325532
8.
Developmental profile of SK2 channel expression and function in CA1 neurons.
Hippocampus
; 22(6): 1467-80, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22072564
9.
Experimental factors that impact CaV1.2 channel pharmacology-Effects of recording temperature, charge carrier, and quantification of drug effects on the step and ramp currents elicited by the "step-step-ramp" voltage protocol.
PLoS One
; 17(11): e0276995, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36417390
10.
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss.
J Pharmacol Toxicol Methods
; 117: 107193, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35792285
11.
New science, drug regulation, and emergent public health issues: The work of FDA's division of applied regulatory science.
Front Med (Lausanne)
; 9: 1109541, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36743666
12.
Translational Models and Tools to Reduce Clinical Trials and Improve Regulatory Decision Making for QTc and Proarrhythmia Risk (ICH E14/S7B Updates).
Clin Pharmacol Ther
; 109(2): 319-333, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33332579
13.
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block.
PLoS One
; 15(11): e0241362, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33157550
14.
A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model.
J Pharmacol Toxicol Methods
; 105: 106890, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32574700
15.
Drug potency on inhibiting late Na+ current is sensitive to gating modifier and current region where drug effects were measured.
J Pharmacol Toxicol Methods
; 100: 106605, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31255744
16.
Assessment of an In Silico Mechanistic Model for Proarrhythmia Risk Prediction Under the CiPA Initiative.
Clin Pharmacol Ther
; 105(2): 466-475, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30151907
17.
Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity.
J Pharmacol Toxicol Methods
; 88(Pt 2): 109-122, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28830713
18.
Corrigendum: Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.
Front Physiol
; 8: 1025, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29230183
19.
Uncertainty Quantification Reveals the Importance of Data Variability and Experimental Design Considerations for in Silico Proarrhythmia Risk Assessment.
Front Physiol
; 8: 917, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29209226
20.
Optimization of an In silico Cardiac Cell Model for Proarrhythmia Risk Assessment.
Front Physiol
; 8: 616, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28878692