Detalles de la búsqueda
1.
Discovery of a potent and selective CBP bromodomain inhibitor (Y08262) for treating acute myeloid leukemia.
Bioorg Chem
; 142: 106950, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37924753
2.
Liver receptor homolog-1: structures, related diseases, and drug discovery.
Acta Pharmacol Sin
; 2024 Apr 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38632319
3.
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer.
Acta Pharmacol Sin
; 2024 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38698214
4.
Optimization of the synthesis of BET BD2 selective inhibitor XY153.
Chem Biodivers
; 21(2): e202301584, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38163253
5.
Rational design, synthesis and biological evaluation of benzo[d]isoxazole derivatives as potent BET bivalent inhibitors for potential treatment of prostate cancer.
Bioorg Chem
; 135: 106495, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37004437
6.
Structural insights revealed by the cocrystal structure of CCS1477 in complex with CBP bromodomain.
Biochem Biophys Res Commun
; 623: 17-22, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35868068
7.
Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol Sin
; 43(10): 2735-2748, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35264812
8.
Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo[d]isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities.
Bioorg Chem
; 94: 103424, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31776034
9.
Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists.
Acta Pharmacol Sin
; 37(11): 1516-1524, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27374490
10.
Discovery of a Promising CBP/p300 Degrader XYD129 for the Treatment of Acute Myeloid Leukemia.
J Med Chem
; 67(11): 9194-9213, 2024 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38829718
11.
Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity.
J Med Chem
; 67(9): 6952-6986, 2024 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-38649304
12.
Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor ß Agonist.
J Med Chem
; 65(10): 7193-7211, 2022 05 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-35507418
13.
Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
J Med Chem
; 65(1): 785-810, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34962793
14.
Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4(5H)-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors.
J Med Chem
; 65(7): 5760-5799, 2022 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35333526
15.
Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist.
J Med Chem
; 64(12): 8775-8797, 2021 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34121397
16.
Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist.
J Med Chem
; 62(24): 11019-11021, 2019 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31751137
17.
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.
J Med Chem
; 62(9): 4716-4730, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30964293
18.
Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC).
J Med Chem
; 61(7): 3037-3058, 2018 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29566488
19.
Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation.
Eur J Med Chem
; 116: 13-26, 2016 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-27043267
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