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1.
SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance.
Mol Cancer Ther
; 21(1): 3-15, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34737197
2.
2-(6-Bromo-3-pyrid-yl)-8-methyl-imidazo[1,2-a]pyrazine.
Acta Crystallogr Sect E Struct Rep Online
; 66(Pt 7): o1723, 2010 Jun 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21587940
3.
Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase.
J Med Chem
; 62(17): 7669-7683, 2019 09 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31415173
4.
Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy.
Mol Cancer Ther
; 17(12): 2530-2542, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30232146
5.
Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497).
J Med Chem
; 61(3): 650-665, 2018 02 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29211475
6.
Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.
J Med Chem
; 60(23): 9617-9629, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29111717
7.
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(18): 8306-25, 2016 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27512831
8.
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
J Med Chem
; 54(9): 3368-85, 2011 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-21438541
9.
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.
J Med Chem
; 59(24): 11196, 2016 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-27936698
10.
Design of selective, ATP-competitive inhibitors of Akt.
J Med Chem
; 53(12): 4615-22, 2010 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20481595
11.
Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold.
J Org Chem
; 67(14): 4882-92, 2002 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-12098301
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