Detalles de la búsqueda
1.
In Vitro ADME and Preclinical Pharmacokinetics of Ulotaront, a TAAR1/5-HT1A Receptor Agonist for the Treatment of Schizophrenia.
Pharm Res
; 39(5): 837-850, 2022 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-35484370
2.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-33051248
3.
Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators.
Bioorg Med Chem Lett
; 30(4): 126852, 2020 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31898999
4.
Effects of organizational commitment, job satisfaction and workplace violence on turnover intention of emergency nurses: A cross-sectional study.
Int J Nurs Pract
; 26(6): e12854, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32529786
5.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30622164
6.
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Xenobiotica
; 49(7): 852-862, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-30132394
7.
Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics.
Drug Metab Dispos
; 46(11): 1692-1702, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30076203
8.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos
; 46(2): 189-196, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29138286
9.
Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study.
Drug Metab Dispos
; 46(7): 943-952, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29695616
10.
Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K.
Pharm Res
; 35(8): 159, 2018 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29915999
11.
A pre-clinical quantitative model predicts the pharmacokinetics/pharmacodynamics of an anti-BDCA2 monoclonal antibody in humans.
J Pharmacokinet Pharmacodyn
; 45(6): 817-827, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30377889
12.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26669328
13.
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.
Drug Metab Dispos
; 44(11): 1752-1758, 2016 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27543206
14.
[Quantitative structure characteristics and fractal dimension of Chinese medicine granules measured by synchrotron radiation X-ray computed micro tomography].
Yao Xue Xue Bao
; 50(6): 767-74, 2015 Jun.
Artículo
en Zh
| MEDLINE | ID: mdl-26521451
15.
Evaluation of OCT2-mediated drug-drug interactions between ulotaront and metformin in subjects with schizophrenia.
Pharmacol Res Perspect
; 12(2): e1191, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38527949
16.
Variability in P-glycoprotein inhibitory potency (IC50) using various in vitro experimental systems: implications for universal digoxin drug-drug interaction risk assessment decision criteria.
Drug Metab Dispos
; 41(7): 1347-66, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23620485
17.
Application of receiver operating characteristic analysis to refine the prediction of potential digoxin drug interactions.
Drug Metab Dispos
; 41(7): 1367-74, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23620486
18.
A Phase I, Open-Label, Fixed Sequence Study to Investigate the Effect of Cytochrome P450 2D6 Inhibition on the Pharmacokinetics of Ulotaront in Healthy Subjects.
Clin Pharmacokinet
; 62(12): 1755-1763, 2023 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37882999
19.
Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates.
Drug Metab Dispos
; 40(4): 779-87, 2012 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-22266779
20.
Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
AAPS J
; 24(5): 85, 2022 07 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35854202