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1.
Molecular Determinants for Protein Stabilization by Insertional Fusion to a Thermophilic Host Protein.
Chembiochem
; 16(16): 2392-402, 2015 Nov 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-26391210
2.
Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.
J Med Chem
; 66(21): 14912-14927, 2023 11 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37861679
3.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34967623
4.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36475697
5.
Stability of a guest protein depends on stability of a host protein in insertional fusion.
Biotechnol Bioeng
; 108(5): 1011-20, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21190177
6.
Protein engineering strategies for improving the selective methylation of target CpG sites by a dCas9-directed cytosine methyltransferase in bacteria.
PLoS One
; 13(12): e0209408, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30562388
7.
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.
Sci Rep
; 7(1): 6732, 2017 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28751638
8.
The interplay between effector binding and allostery in an engineered protein switch.
Protein Sci
; 25(9): 1605-16, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27272021
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