Detalles de la búsqueda
1.
Discovery of novel harmine derivatives as GSK-3ß/DYRK1A dual inhibitors for Alzheimer's disease treatment.
Arch Pharm (Weinheim)
; 357(2): e2300404, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38010470
2.
Integrated UHPLC-QE/MS, transcriptomics and network pharmacology reveal the mechanisms via which Liang-Yan-Yi-Zhen-San promotes the browning of white adipose tissue.
Biomed Chromatogr
; 37(12): e5734, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37822161
3.
An integrated multi-omics approach revealed the regulation of melatonin on age-dependent mitochondrial function impair and lipid dyshomeostasis in mice hippocampus.
Pharmacol Res
; 179: 106210, 2022 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35398524
4.
Design, synthesis, and biological evaluation of ß-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects.
Bioorg Med Chem Lett
; 64: 128663, 2022 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35272009
5.
Facile synthesis of C1-substituted ß-carbolines as CDK4 inhibitors for the treatment of cancer.
Bioorg Chem
; 121: 105659, 2022 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-35180487
6.
Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors.
Bioorg Chem
; 126: 105870, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636125
7.
Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property.
Bioorg Chem
; 126: 105875, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35623141
8.
Discovery of novel ß-carboline-1,2,3-triazole hybrids as AChE/GSK-3ß dual inhibitors for Alzheimer's disease treatment.
Bioorg Chem
; 129: 106168, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36191431
9.
Discovery of novel α-carboline derivatives as glycogen synthase kinase-3ß inhibitors for the treatment of Alzheimer's disease.
Arch Pharm (Weinheim)
; 355(10): e2200156, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35836098
10.
LC-ESI-MS/MS analysis and pharmacokinetics of GP205, an innovative potent macrocyclic inhibitor of hepatitis C virus NS3/4A protease in rats.
Molecules
; 20(3): 4319-36, 2015 Mar 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-25756650
11.
Neutrophil extracellular traps formation may be involved in the association of propranolol with the development of portal vein thrombosis.
Thromb Res
; 238: 208-221, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38733693
12.
Correction to Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3ß for the Treatment of Alzheimer's Disease.
ACS Omega
; 8(1): 1723, 2023 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36643555
13.
An inhibitor with GSK3ß and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease.
Neuropharmacology
; 232: 109525, 2023 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37004752
14.
Pharmacokinetics, tissue distribution, and antitumor activity of a novel compound, NY-2, in non-small cell lung cancer.
Front Pharmacol
; 13: 1074576, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36726788
15.
Inhibition of Angiogenesis and Extracellular Matrix Remodeling: Synergistic Effect of Renin-Angiotensin System Inhibitors and Bevacizumab.
Front Oncol
; 12: 829059, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35847929
16.
Exploration of the Components and Pharmacological Mechanisms of Keyin Pill-Induced Liver Injury Based on Network Pharmacology.
Evid Based Complement Alternat Med
; 2022: 9916949, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36518852
17.
Yuan-Zhi decoction in the treatment of Alzheimer's disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and experimental evaluation.
Front Pharmacol
; 13: 893244, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36091836
18.
Discovery of novel ß-carboline derivatives as selective AChE inhibitors with GSK-3ß inhibitory property for the treatment of Alzheimer's disease.
Eur J Med Chem
; 229: 114095, 2022 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-34995924
19.
Design, synthesis and biological evaluation of novel coumarin derivatives as multifunctional ligands for the treatment of Alzheimer's disease.
Eur J Med Chem
; 242: 114689, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36007469
20.
Development and structure-activity relationship of tacrine derivatives as highly potent CDK2/9 inhibitors for the treatment of cancer.
Eur J Med Chem
; 242: 114701, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36054949