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1.
T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production.
Biochem Biophys Res Commun
; 479(2): 179-185, 2016 10 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27608596
2.
An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).
Biochem Biophys Res Commun
; 480(3): 380-386, 2016 Nov 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-27771247
3.
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg Med Chem
; 21(18): 5725-37, 2013 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23928071
4.
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
Bioorg Med Chem
; 21(24): 7938-54, 2013 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24169315
5.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 3. Evaluation of 5-amino-linked thiazolo[5,4-d]pyrimidine and thiazolo[5,4-b]pyridine derivatives.
Bioorg Med Chem
; 20(18): 5600-15, 2012 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22883026
6.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors: 2. Synthesis and characterization of a novel imide-type prodrug for improving oral absorption.
Bioorg Med Chem
; 20(15): 4680-92, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22763369
7.
Gene Signature-Based Approach Identified MEK1/2 as a Potential Target Associated With Relapse After Anti-TNFα Treatment for Crohn's Disease.
Inflamm Bowel Dis
; 24(6): 1251-1265, 2018 05 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-29669006
8.
Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy.
PLoS One
; 12(10): e0186587, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-29065190
9.
A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells.
Mol Cancer Ther
; 16(2): 273-284, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27903753
10.
Antitumor activity and pharmacodynamic biomarkers of a novel and orally available small-molecule antagonist of inhibitor of apoptosis proteins.
Mol Cancer Ther
; 12(2): 230-40, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23243058
11.
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
J Med Chem
; 56(16): 6478-94, 2013 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-23906342
12.
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
J Med Chem
; 56(3): 1228-46, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-23298277
13.
Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.
J Med Chem
; 55(7): 3452-78, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22376051
14.
Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis.
Genes Cells
; 12(7): 853-61, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17584297
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