Detalles de la búsqueda
1.
Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation in Acquired Etoposide-Resistant Human Leukemia K562 Cells.
Mol Pharmacol
; 106(1): 33-46, 2024 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38719474
2.
Use of CRISPR/Cas9 with Homology-Directed Repair to Gene-Edit Topoisomerase IIß in Human Leukemia K562 Cells: Generation of a Resistance Phenotype.
J Pharmacol Exp Ther
; 389(2): 186-196, 2024 Apr 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38508753
3.
Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs.
Antimicrob Agents Chemother
; 67(10): e0048223, 2023 10 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-37724886
4.
Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIß Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide.
J Pharmacol Exp Ther
; 384(2): 265-276, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36410793
5.
Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks.
Int J Mol Sci
; 24(15)2023 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-37569485
6.
Discovery of Anticancer Agents of Diverse Natural Origin.
J Nat Prod
; 85(3): 702-719, 2022 03 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35213158
7.
CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5' Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells.
Mol Pharmacol
; 99(3): 226-241, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33446509
8.
hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide.
Mol Pharmacol
; 97(3): 159-170, 2020 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-31836624
9.
The Novel C-terminal Truncated 90-kDa Isoform of Topoisomerase IIα (TOP2α/90) Is a Determinant of Etoposide Resistance in K562 Leukemia Cells via Heterodimerization with the TOP2α/170 Isoform.
Mol Pharmacol
; 93(5): 515-525, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29514855
10.
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.
Bioorg Med Chem Lett
; 28(14): 2477-2480, 2018 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29871847
11.
Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.
Bioorg Med Chem
; 26(9): 2354-2364, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29656990
12.
Capsicodendrin from Cinnamosma fragrans Exhibits Antiproliferative and Cytotoxic Activity in Human Leukemia Cells: Modulation by Glutathione.
J Nat Prod
; 81(3): 625-629, 2018 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-29406734
13.
Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform.
J Pharmacol Exp Ther
; 360(1): 152-163, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27974648
14.
TRIM72 modulates caveolar endocytosis in repair of lung cells.
Am J Physiol Lung Cell Mol Physiol
; 310(5): L452-64, 2016 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26637632
15.
Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform.
J Pharmacol Exp Ther
; 356(2): 397-409, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26660439
16.
Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.
Bioorg Med Chem
; 23(13): 3542-51, 2015 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25922181
17.
Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
Bioorg Med Chem
; 22(21): 5935-49, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25282653
18.
Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.
J Nat Prod
; 77(6): 1494-504, 2014 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24937209
19.
Use of CRISPR/Cas9 with homology-directed repair to silence the human topoisomerase IIα intron-19 5' splice site: Generation of etoposide resistance in human leukemia K562 cells.
PLoS One
; 17(5): e0265794, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35617303
20.
Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα.
Cancers (Basel)
; 14(13)2022 Jun 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35804920