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1.
Development of novel steroid sulfatase inhibitors; II. TZS-8478 potently inhibits the growth of breast tumors in postmenopausal breast cancer model rats.
J Steroid Biochem Mol Biol
; 88(2): 167-73, 2004 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15084348
2.
Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.
J Med Chem
; 53(21): 7549-63, 2010 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20931963
3.
Design and synthesis of piperazinylpyridine derivatives as novel 5-HT1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS).
Chem Pharm Bull (Tokyo)
; 57(1): 34-42, 2009 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19122313
4.
Pharmacological properties of 3-amino-5,6,7,8-tetrahydro-2-[4-[4-(quinolin-2-yl)piperazin-1-yl]butyl]quinazolin-4(3H)-one (TZB-30878), a novel therapeutic agent for diarrhea-predominant irritable bowel syndrome (IBS) and its effects on an experimental IBS model.
J Pharmacol Exp Ther
; 322(3): 1315-23, 2007 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-17540858
5.
[Pathophysiological role of endothelin-1 in the vascular remodeling process].
Nihon Yakurigaku Zasshi
; 120(1): 79P-81P, 2002 Nov.
Artículo
en Japonés
| MEDLINE | ID: mdl-12491787
6.
Possible involvement of facilitated polyol pathway in augmentation of intimal hyperplasia in rabbits with alloxan-induced hyperglycemia.
J Cardiovasc Pharmacol
; 41(2): 265-75, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12548088
7.
Accumulated endogenous nitric oxide synthase inhibitors in inhibiting urethral relaxation following estrogen supplementation in ovariectomized rabbits.
J Urol
; 172(1): 360-4, 2004 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15201811
8.
Involvement of increased arginase activity in impaired cavernous relaxation with aging in the rabbit.
J Urol
; 172(1): 369-73, 2004 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-15201813
9.
Effects of the novel orally active antiestrogen TZE-5323 on experimental endometriosis.
Arzneimittelforschung
; 53(7): 507-14, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12918217
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