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1.
Hydrolase Activity of the Genetic Variants of Human Alpha-1-Acid Glycoprotein.
Mol Pharm
; 19(3): 798-804, 2022 03 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35179021
2.
Human Immortalized Cell-Based Blood-Brain Barrier Spheroid Models Offer an Evaluation Tool for the Brain Penetration Properties of Macromolecules.
Mol Pharm
; 19(8): 2754-2764, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35766901
3.
In Vitro-In Vivo Correlation of Blood-Brain Barrier Permeability of Drugs: A Feasibility Study Towards Development of Prediction Methods for Brain Drug Concentration in Humans.
Pharm Res
; 39(7): 1575-1586, 2022 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-35288803
4.
Species Difference in Hydrolysis of an Ester-type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein.
Mol Pharm
; 18(5): 1985-1991, 2021 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33861617
5.
Development, Characterization and Potential Applications of a Multicellular Spheroidal Human Blood-Brain Barrier Model Integrating Three Conditionally Immortalized Cell Lines.
Biol Pharm Bull
; 44(7): 984-991, 2021 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33896887
6.
Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver.
Xenobiotica
; 50(5): 526-535, 2020 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-31491346
7.
A Human Immortalized Cell-Based Blood-Brain Barrier Triculture Model: Development and Characterization as a Promising Tool for Drug-Brain Permeability Studies.
Mol Pharm
; 16(11): 4461-4471, 2019 11 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31573814
8.
Quantification of ONO-2952 Occupancy of 18-kDaTranslocator Protein in Conscious Monkey Brains using Positron Emission Tomography.
J Pharmacol Exp Ther
; 360(3): 457-465, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-27986860
9.
Species Difference in Hydrolysis of an Ester-Type Prodrug of Levodopa in Human and Animal Plasma: Different Contributions of Alpha-1 Acid Glycoprotein.
Mol Pharm
; 19(9): 3450, 2022 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35900112
10.
Development of a microphysiological model of human kidney proximal tubule function.
Kidney Int
; 90(3): 627-37, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27521113
11.
Functional Comparison of Human Colonic Carcinoma Cell Lines and Primary Small Intestinal Epithelial Cells for Investigations of Intestinal Drug Permeability and First-Pass Metabolism.
Drug Metab Dispos
; 44(3): 329-35, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26700954
12.
Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.
Bioorg Med Chem Lett
; 26(4): 1209-13, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26794040
13.
Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.
Bioorg Med Chem Lett
; 25(20): 4387-92, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26384288
14.
Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.
Xenobiotica
; 45(4): 312-21, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25364857
15.
Age-related pharmacokinetic changes of acetaminophen, antipyrine, diazepam, diphenhydramine, and ofloxacin in male cynomolgus monkeys and beagle dogs.
Xenobiotica
; 44(10): 893-901, 2014 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-24650193
16.
Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney.
CPT Pharmacometrics Syst Pharmacol
; 11(7): 919-933, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35570332
17.
Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions.
Clin Pharmacol Ther
; 111(6): 1315-1323, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35292967
18.
Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs.
Clin Transl Sci
; 15(6): 1519-1531, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35421902
19.
Discovery of orally available 8-aza-5-thiaProstaglandin E1 analogs as highly selective EP4 agonists.
Chem Pharm Bull (Tokyo)
; 59(12): 1523-34, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-22130375
20.
3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.
Bioorg Med Chem
; 18(9): 3212-23, 2010 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20385498