Detalles de la búsqueda
1.
Recent advances in antibacterial agents.
Bioorg Med Chem Lett
; 35: 127799, 2021 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33476772
2.
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer.
Bioorg Med Chem
; 31: 115953, 2021 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33388655
3.
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.
Bioorg Med Chem Lett
; 29(6): 848-852, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30685095
4.
Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents.
Arch Pharm (Weinheim)
; 352(11): e1900129, 2019 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-31478565
5.
Design, synthesis, and structure-activity relationship studies of novel tetrazole antifungal agents with potent activity, broad antifungal spectrum and high selectivity.
Bioorg Med Chem Lett
; 28(3): 344-350, 2018 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29289430
6.
Design, synthesis and structure-activity relationship evaluation of novel LpxC inhibitors as Gram-negative antibacterial agents.
Bioorg Med Chem Lett
; 28(2): 94-102, 2018 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29233653
7.
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles.
Bioorg Med Chem
; 26(22): 5780-5791, 2018 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30392954
8.
Synthesis and structure-activity relationship studies of novel [6,6,5] tricyclic oxazolidinone derivatives as potential antibacterial agents.
Bioorg Med Chem Lett
; 25(10): 2203-10, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25838143
9.
Discovery of YFJ-36: Design, Synthesis, and Antibacterial Activities of Catechol-Conjugated ß-Lactams against Gram-Negative Bacteria.
J Med Chem
; 67(8): 6705-6725, 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38596897
10.
Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria.
J Med Chem
; 67(8): 6585-6609, 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38598362
11.
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents.
Bioorg Med Chem Lett
; 23(13): 3697-9, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23721807
12.
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer.
J Med Chem
; 66(14): 9972-9991, 2023 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37458396
13.
Design, synthesis, and structure-activity relationship studies of conformationally restricted mutilin 14-carbamates.
Bioorg Med Chem Lett
; 22(2): 814-9, 2012 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22209487
14.
Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability.
J Med Chem
; 65(7): 5724-5750, 2022 04 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35357160
15.
Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer.
J Med Chem
; 65(18): 12460-12481, 2022 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36070471
16.
Design, Synthesis, and Structure-Activity Relationship Studies of Bisamide Derivatives of Amphotericin B with Potent Efficacy and Low Toxicity.
J Med Chem
; 65(13): 8897-8913, 2022 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35786969
17.
Design and synthesis of pyridine-substituted itraconazole analogues with improved antifungal activities, water solubility and bioavailability.
Bioorg Med Chem Lett
; 21(16): 4779-83, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21764309
18.
T33, a novel peroxisome proliferator-activated receptor γ/α agonist, exerts neuroprotective action via its anti-inflammatory activities.
Acta Pharmacol Sin
; 32(9): 1100-8, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21804572
19.
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.
J Med Chem
; 64(12): 8644-8665, 2021 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34080858
20.
Enantioselective total synthesis of (-)-(S)-stepholidine.
J Org Chem
; 74(23): 9225-8, 2009 Dec 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19950885