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1.
Microbial dietary protein metabolism regulates GLP-1 mediated intestinal transit.
FASEB J
; 37(10): e23201, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37732618
2.
Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.
Bioorg Med Chem
; 93: 117462, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37683572
3.
Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model.
J Pharmacol Exp Ther
; 379(3): 280-289, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34535562
4.
Enteropeptidase inhibition improves obesity by modulating gut microbiota composition and enterobacterial metabolites in diet-induced obese mice.
Pharmacol Res
; 163: 105337, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33276106
5.
Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease.
Alcohol Clin Exp Res
; 45(10): 2103-2117, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34486129
6.
SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice.
Diabetes Obes Metab
; 21(10): 2228-2239, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31144422
7.
Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.
Bioorg Med Chem
; 25(15): 4175-4193, 2017 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28642028
8.
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).
Nat Metab
; 2024 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-38867022
9.
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.
J Pharmacol Exp Ther
; 340(2): 483-9, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22106100
10.
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7326-9, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23147077
11.
Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.
J Med Chem
; 65(12): 8456-8477, 2022 06 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35686954
12.
Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis.
JHEP Rep
; 3(2): 100217, 2021 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-33490936
13.
Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.
PLoS One
; 15(1): e0228212, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-31990961
14.
Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.
Pharmacol Res Perspect
; 7(5): e00517, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31508234
15.
A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.
PLoS One
; 11(11): e0166198, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27832159
16.
Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.
J Med Chem
; 54(3): 831-50, 2011 Feb 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21218817
17.
Design of a new high repetition rate Nd:YAG Thomson scattering system for Heliotron J.
Rev Sci Instrum
; 81(10): 10D532, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21033887
18.
The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump.
J Biol Chem
; 279(14): 13968-75, 2004 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-14699149
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