Detalles de la búsqueda
1.
A small-molecule activation mechanism that directly opens the KCNQ2 channel.
Nat Chem Biol
; 2024 Jan 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38167918
2.
Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD.
Bioorg Med Chem
; 96: 117511, 2023 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37976806
3.
Coronarin A modulated hepatic glycogen synthesis and gluconeogenesis via inhibiting mTORC1/S6K1 signaling and ameliorated glucose homeostasis of diabetic mice.
Acta Pharmacol Sin
; 44(3): 596-609, 2023 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-36085523
4.
Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio.
Bioorg Med Chem
; 43: 116280, 2021 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34256254
5.
SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice.
Acta Pharmacol Sin
; 42(11): 1834-1846, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33574568
6.
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition.
Acta Pharmacol Sin
; 37(10): 1359-1369, 2016 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-27264313
7.
Discovery and Structure-Activity Relationship Study of 4-Phenoxythiazol-5-carboxamides as Highly Potent TGR5 Agonists.
Chem Pharm Bull (Tokyo)
; 64(4): 326-39, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26843013
8.
Phenotypic screening-based drug discovery of furan-2-carboxylic acid derivatives for the amelioration of type 2 diabetes mellitus (T2DM).
Eur J Med Chem
; 246: 114994, 2023 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36493615
9.
General Pharmacological Activation Mechanism of K+ Channels Bypassing Channel Gates.
J Med Chem
; 65(15): 10285-10299, 2022 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35878013
10.
Pyrimidinyl-arylpropionic acid derivatives: viable resources in the development of new antineoplastic agents.
Invest New Drugs
; 28(4): 472-81, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19533021
11.
Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects.
Eur J Med Chem
; 203: 112619, 2020 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32682201
12.
Antitumor activity of a novel series of alpha-aryloxy-alpha-methylhydrocinnamic acid derivatives as PPAR gamma agonists against a panel of human cancer cell lines.
Invest New Drugs
; 27(3): 223-32, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18704263
13.
Discovery of novel dual functional agent as PPARgamma agonist and 11beta-HSD1 inhibitor for the treatment of diabetes.
Bioorg Med Chem
; 17(15): 5722-32, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19574056
14.
Antitumor efficacy of two novel non-thiazolidinedione compounds as peroxisome proliferator-activated receptor-gamma agonists in human osteosarcoma cells in vitro.
Chemotherapy
; 55(6): 468-76, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19996593
15.
TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice.
Metabolism
; 99: 45-56, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31295453
16.
Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker.
Eur J Med Chem
; 152: 175-194, 2018 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29705709
17.
Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3.
Front Pharmacol
; 9: 476, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29867482
18.
Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects.
Curr Med Chem
; 24(35): 3921-3937, 2017 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28799499
19.
Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect.
Sci Rep
; 6: 28676, 2016 06 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27339735
20.
Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes.
J Med Chem
; 58(8): 3315-28, 2015 Apr 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-25710631