Detalles de la búsqueda
1.
Comprehensive gene profiling of the metabolic landscape of humanized livers in mice.
J Hepatol
; 80(4): 622-633, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-38049085
2.
HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes.
Biochem Biophys Res Commun
; 663: 132-141, 2023 06 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121123
3.
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers.
Drug Metab Dispos
; 51(4): 480-491, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36623885
4.
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers.
Xenobiotica
; 53(8-9): 523-535, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37938160
5.
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes.
Xenobiotica
; 52(3): 229-239, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-35416115
6.
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes.
Xenobiotica
; 51(5): 582-589, 2021 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-33455497
7.
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers.
Xenobiotica
; 51(10): 1146-1154, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-34423713
8.
Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds.
Genes Cells
; 24(7): 473-484, 2019 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-31099158
9.
Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
Drug Metab Dispos
; 48(7): 580-586, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32357972
10.
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes.
Xenobiotica
; 50(6): 733-740, 2020 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-31690163
11.
Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers.
Xenobiotica
; 49(6): 678-687, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-29969338
12.
[LATEST ADVANCES IN HEREDITARY ANGIOEDEMA (HAE)].
Arerugi
; 68(8): 919-922, 2019.
Artículo
en Japonés
| MEDLINE | ID: mdl-31534101
13.
Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation.
Drug Metab Pharmacokinet
; 56: 101007, 2024 Mar 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38797091
14.
SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers.
Toxicol Lett
; 388: 48-55, 2023 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37806366
15.
o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice.
Toxicology
; 488: 153483, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36870411
16.
Drug transporter expression and activity in cryopreserved human hepatocytes isolated from chimeric TK-NOG mice with humanized livers.
Toxicol In Vitro
; 90: 105592, 2023 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-37030647
17.
Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers.
Drug Metab Pharmacokinet
; 44: 100454, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-35378494
18.
Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo.
Drug Metab Pharmacokinet
; 44: 100453, 2022 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-35381575
19.
An improved TK-NOG mouse as a novel platform for humanized liver that overcomes limitations in both male and female animals.
Drug Metab Pharmacokinet
; 42: 100410, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-34839181
20.
Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes.
Drug Metab Pharmacokinet
; 41: 100419, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34624627